Surgery – Truss – Pad
Patent
1995-05-03
1997-11-04
Smith, Ruth S.
Surgery
Truss
Pad
1286533, 1286534, A61B 5055
Patent
active
056828837
ABSTRACT:
An apparatus and method of imaging a human body portion of a living person via magnetic resonance of oxygen-17 constituents in the living person. In the method, a static magnetic field of a selected magnitude is generated around the living person, the selected magnitude not being substantially greater than 1.5 Tesla, and a resonant electromagnetic field of a selected frequency is generated around the human body portion. The frequency of the resonant electromagnetic field and the magnitude of the static magnetic field are selected to cause magnetic resonance of oxygen-17 constituents in the human body portion. Oxygen-17 NMR signals generated from the magnetic resonance of the oxygen-17 constituents are received, and an image of the human body portion is generated based upon the oxygen-17 NMR signals. The apparatus and method determine the quantitative rates of blood flow and oxygen consumption in the human body portion based on the inhalation by the living person of a gas containing an oxygen-17 concentration different than the natural abundance concentration of oxygen-17 in air.
REFERENCES:
patent: 3764892 (1973-10-01), Rollwitz
patent: 4354499 (1982-10-01), Damadian
patent: 4411270 (1983-10-01), Damadian
patent: 4536712 (1985-08-01), Iwaoka et al.
patent: 4558279 (1985-12-01), Ackerman et al.
patent: 4586511 (1986-05-01), Clark, Jr.
patent: 4651097 (1987-03-01), Iwaoka et al.
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4922203 (1990-05-01), Sillerud et al.
patent: 4984574 (1991-01-01), Goldberg et al.
patent: 4996041 (1991-02-01), Arai et al.
patent: 5339814 (1994-08-01), Lasker
Arai, et al., "Method for the Detection of Tissue Metabolite (H.sub.2.sup.17 O) in Brain by Proton Magnetic Resonance Imaging," Critical Care Medicine, vol. 17, No. 12, pp. 1333-1334 (1989).
Barr, et al., "Contrast Enhancement with SSFP Techniques Applied to Oxygen 17 Based Contrast Agents".
Bratton, et al., "Nuclear Magnetic Resonance Studies of Living Muscle," Science, vol. 147, pp. 738-739 (Feb. 12, 1965).
Burstein, et al., "Magnetic Resonance Imaging of Intracellular Sodium," Journal of Magnetic Resonance 83, 197-204 (1989).
DeLayre, et al., "Gated Sodium-23 Nuclear Magnetic Resonance Images of an Isolated Perfused Working Rat Heart," Science, vol. 212, pp. 935-936 (May 22, 1981).
Fiat, et al., "Determination of the Rate of Cerebral Oxygen Consumption and Regional Cerebral Blood Flow by Non-Invasive .sup.17 O In Vivo NMR Spectroscopy and Magnetic Resonance Imaging," Neurological Research, vol. 14, pp. 303-311 (Sep. 1992).
Fiat, et al., "Determination of the Rate of Cerebral Oxygen Consumption and Regional Cerebral Blood Flow by Non-Invasive .sup.17 O In Vivo NMR Spectroscopy and Magnetic Resonance Imaging," Neurological Research, vol. 15, pp. 7-22 (Feb. 1993).
Fiat, et al., "Monitoring Cerebral Oxygen Consumption with In Vivo Imaging .sup.17 0 NMR," Presented at the XVth International Symposium on Cerebral Flow and Metabolism, Jun. 1-6, 1991, Miami, Florida.
Fiat, et al., "Monitoring Cerebral Oxygen Consumption In Vivo .sup.17 O NMR," Journal of Cerebral Blood Flow and Metabolism, vol. 11, Supp. 2, p. S781 (1991).
Fiat, et al. "In Vivo .sup.17 O NMR Study of Rat Brain during .sup.17 O.sub.2 Inhalation," Magnetic Resonance in Medicine 24, pp. 370-374, (Apr. 1992).
Fiat, et al., ".sup.17 O NMR and MRI Determination of Cerebral Metabolism of Oxygen (rCMRO.sub.2) and Cerebral Blood Flow (rCBF).sup.1 in the Man" (1993).
Hall, et al., "Mapping of pH and Temperature Distribution Using Chemical-Shift-Resolved Tomography," Journal of Magnetic Resonance 65, pp. 501-505 (1985).
Hopkins, et al., "Improved Sensitivity of Proton MR to Oxygen-17 as a Contrast Agent Using Fast Imaging: Detection in Brain," Magnetic Resonance in Medicine 7, pp. 222-229 (1988).
Hopkins, et al., "Oxygen-17 Compounds as Potential NMR T.sub.2 Contrast Agents: Enrichment Effects of H.sub.2.sup.17 O on Protein Solutions and Living Tissues," Magnetic Resonance in Medicine 4, pp. 399-403 (1987).
Hopkins, et al., "Multiple Field Strength In Vivo T.sub.1 and T.sub.2 for Cerebrospinal Fluid Protons," Magnetic Resonance in Medicine 3, pp. 303-311 (1986).
Hopkins, et al., "On the Monitoring of Proton Exchange Rates of Living Tissue In Situ," Proceedings of the AMPERE Conference on Hertzian Optics and Dielectrics-Sep. 2-4, 1987, Pisa, Italy.
Hopkins, et al., "Physiological Application of .sup.17 O Promoted Proton T.sub.2 Relaxation.sup.a," Annals New York Academy of Sciences, pp. 463-465.
Hsieh, et al., ".sup.31 P Imaging of in Vivo Creatine Kinase Reaction Rates," Journal of Magnetic Resonance 74, pp. 574-579 (1987).
Joseph, et al., "In Vivo .sup.19 F NMR Imaging of the Cardiovascular System," Journal of Computer Assisted Tomography, vol. 9, No. 6, pp. 1012-1019 (1985).
Kety, "The Theory and Applications of the Exchange of Inert Gas at the lungs and Tissues," Pharmacological Reviews, vol. 3, pp. 1-41 (1951).
Kwong, et al., "Quantitative Single-Shot Imaging with H.sub.2 of the Effect of pco.sub.2 on Regional Cerebral Blood Flow with H.sub.2.sup.17 O," JMRI, p. 192 (Mar./Apr. 1991).
Lasker, et al., "Proton NMR Imaging of Myocardial Reperfusion Injury by Visualization of Metabolites of Oxygen-17," Ninth Annual Scientific Meeting and Exhibition, p. 1202 (Aug. 18-24, 1990).
Link, et al., "Comparison of Deuterium NMR Imaging Methods and Applications to Plants," Journal of Magnetic Resonance 89, pp. 310-330, (1990).
McFarland, et al., "Chemical Exchange Magnetic Resonance Imaging (Chemi)," Magnetic Resonance Imaging, vol. 6, pp. 507-515 (1988).
Mateescu, et al., "The Hydronium Ion (H.sub.3 O.sup.+). Preparation and Characterization by High Resolution Oxygen-17 Nuclear Magnetic Resonance," Journal of the American Chemical Society, 101: 14, 3959-3960, (Jul. 4, 1979).
Mateescu, et al., "Water, Ions and O-17 Magnetic Resonance Imaging," Water and Ions in Biological Systems, pp. 239-250 (1988).
Mateescu, et al., "Oxygen-17 MRS: In Vivo Evaluation of Water Uptake and Residence Time in the Mouse Brain after Injection of O-17 Labelled Water," p. 1236 (1990).
Mateescu, et al., "Oxygen-17 MRI and MRS of the Brain, the Heart and Coronary Arteries," (1989).
Mateescu, et al., "Oxygen-17: A Physiological, Biochemical and Anatomical MRI Contrast Agent," Society of Magnetic Resonance in Medicine, p. 600 (1988).
Mateescu, et al., "In Vivo Determination of Oxygen Utilization by Localized .sup.17 O Magnetic Resonance Spectroscopy: Detection of Metabolic Water In Mice Breathing .sup.17 O-Enriched Air," (1991).
Mateescu, et al., "Oxygen-17 Magnetic Resonance Imaging.sup.1," p. 929 (1987).
Mateescu, et al. "Oxygen-17 Magnetic Resonance: In Vivo Detection of Nascent Mitochondrial Water in Animals Breathing .sup.17 O.sub.2 Enriched Air," Society of Magnetic Resonance in Medicine (1991).
Mateescu, et al., "Combined .sup.17 O.sup.1 H Magnetic Resonance Microscopy in Plants, Animals and Materials: Present Status and Potential," Synthesis and Applications of Isotopically Labelled Compounds, pp. 499-508 (1988).
Maudsley, et al., "Spatially Resolved High Resolution Spectroscopy by `Four-Dimensional` NMR," Journal of Magnetic Resonance 51, pp. 147-152 (1983).
Nunnally, et al., "Flourine-19 NMR Spectroscopy and Imaging Investigations of Myocardial Perfusion and Cardiac Function," Magnetic Resonance Imaging, vol. 3, pp. 399-405, (1985).
Pekar, et al., "In Vivo Measurement of Cerebral Oxygen Consumption and Blood Flow Using .sup.17 O Magnetic Resonance Imaging," Magnetic Resonance in Medicine 21, pp. 313-319 (1991).
Renshaw, et al., "In Vivo Nuclear Magnetic Resonance Imaging of Lithium," Magnetic Resonance in Medicine 2, pp. 512-516 (1985).
Renshaw, et al., "Relaxation and Imaging of Lithium in Vivo," Magnetic Resonance Imaging, vol. 4, pp. 193-198 (1986).
Schnall, et al., "A New Double-Tuned Probe for Concurrent .sup.1 H and .sup.31 P NMR," Journal of Magnetic Resonance 65, pp. 122-129 (1985).
Thomas, et al. "MR Imaging of the Lung Using Liquid Perfluorocarbons," Journal of Computer Assisted Tomography, vol. 10, No. 1, pp. 1-9 (1986).
Young, "Magnetic Resonance Imaging: Basic
Board of Trustees of the University of Illinois
Smith Ruth S.
LandOfFree
Oxygen-17 NMR method of determining the quantitative rate of blo does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxygen-17 NMR method of determining the quantitative rate of blo, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxygen-17 NMR method of determining the quantitative rate of blo will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1825335