Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-03-17
1979-11-27
Thomas, Jr., James O.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424316, 424319, 424324, 260558A, 260448R, 560 35, 562440, A61K 3124, C07C13100
Patent
active
041761944
ABSTRACT:
The invention concerns novel diarylmethyleneamino-oxyalkanoic acid derivatives which possess useful analgesic properties in warm-blooded animals. In addition certain of the derivatives also possess useful anti-inflammatory properties. Accordingly, the invention embraces oxyalkanoic acids, and simple esters and amides and non-toxic salts thereof, of the general formula: ##STR1## together with pharmaceutical compositions thereof, for use in the treatment of painful inflammatory joint diseases. In addition, the invention provides as a further feature various analogy processes for the manufacture of compounds of formula I.
A representative compound of the invention is di-(4-chlorophenyl)methyleneamino-oxyacetic acid which has both analgesic and anti-inflammatory properties.
REFERENCES:
patent: 3853955 (1974-12-01), Van Dijk et al.
patent: 4071686 (1978-01-01), Van Dijk et al.
Forrester et al, Chem. Soc., Chem. Commun., (8), pp. 291-292, (1975).
Breitenstein G. T.
Imperial Chemical Industries Limited
Thomas, Jr. James O.
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