Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-03-08
2005-03-08
Lambkin, Deborah C. (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S473000, C549S475000, C549S476000, C549S480000, C549S216000, C549S218000
Reexamination Certificate
active
06864283
ABSTRACT:
Compounds of formula (I) wherein R1is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18alkynyl, or substituted or unsubstituted aryl; or R1together with R2forms a saturated or unsaturated heterocyclic ring; R2and R3are each, independently, selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18alkynyl, or substituted or unsubstituted aryl; or one of R2or R3together with R1forms a saturated or unsaturated heterocyclic ring; or R2and R3together form a saturated or unsaturated heterocyclic ring; R4is selected from H, C(═O)R′, P(═O)R′R″, S(═O)R′R″, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18, alkynyl, or substituted or unsubstituted aryl, wherein R′ is selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18alkynyl, substituted and unsubstituted aryl; R″ is selected from the group consisting of H, OH, NO2, NH2, SH, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18alkynyl, substituted and unsubstituted aryl; wherein X1, X2X3on formula I are independently placed in any particular position of the chain and independently selected from H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHC(O)R′, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaromatic, wherein substituent groups defined by R′ are each independently selected from the group consisting of H, OH, OR′, SH, SR′, SOR′, SO2R′, NO2, NH2, NHR′, N(R′)2, NHC(O)R′, CN, halogen, ═O, C(═O)H, C(═O)CH3, CO2H, CO2CH3, substituted or unsubstituted C1-C18alkyl, substituted or unsubstituted C2-C18alkenyl, substituted or unsubstituted C2-C18alkynyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaromatic; wherein x is 6 to 20; and wherein the dotted lined is one or several optional double bonds placed in any particular position of the side chain; or pharmaceutically acceptable salts thereof are useful as antitumor compounds and include compound IK-8-73-4 of structure (a) which was isolated from a spongePachastrissasp.
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Garcia Gravalos Dolores
Higa Tatsuo
Tanaka Junichi
Fish & Richardson P.C.
Pharma Mar S.A.
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