Oxotetrahydrothiophenes

Details Oxotetrahydrothiophenes Oxotetrahydrothiophenes

1976-04-06

1982-08-17

Siegel, Alan

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424426, 4242484, 424249, 424250, 424256, 424269, 424274, 424275, 549 63, 549 60, 549 59, 542420, 542406, A61K 3142, A61K 3154, C07D33316, C09B 2316

Patent

active

043449565

ABSTRACT:
Biological activity is retained while reducing toxicity to animals, particularly mammals, e.g. humans, when a physiologically-active and pharmacologically-acceptable compound (having or structurally modified to have an aldehyde function) is condensed with any of the six (mono)amino(mono)oxotetrahydrothiophenes, e.g. homocysteine thiolactone, to form a Schiff Base (a 4-butyrothiolactone-2-imine or .gamma.-thiobutyrolactone-.alpha.-imine). The invention is directed to every Schiff Base which is a condensate of a physiologically-active and pharmacologically-acceptable compound with a (mono)amino(mono)oxotetrahydrothiophene. These Schiff Bases have a unifying common property in reduced toxicity, while maintaining the biological properties "carried" by the imine substituents. They concurrently have at most an insignificant adverse affect on pharmacological activity.

REFERENCES:
patent: 3546216 (1970-12-01), Dunn

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