Oxo propenyl nucleosides and nucleoside related analogs

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

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514 46, 514 49, 514 50, 536 23, 536 24, 536 26, A61K 3170, C07H 1700

Patent

active

046893210

ABSTRACT:
Certain 3-oxo-prop-1-enyl purine and pyrimidine derivatives and the corresponding nucleosides have been prepared. These compounds exhibit interesting and valuable cytotoxic activity. This cytotoxicity is of special interest in that it appears to inhibit DNA reproduction without affecting RNA or protein synthesis.

REFERENCES:
patent: 3376283 (1968-04-01), Hunter
patent: 4171431 (1979-10-01), Skulnick
patent: 4267171 (1981-05-01), Bergstrom et al.

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