Oxo-analogs of mevinolin-like antihyper-cholesterolemic agents

Details Oxo-analogs of mevinolin-like antihyper-cholesterolemic agents Oxo-analogs of mevinolin-like antihyper-cholesterolemic agents

1986-02-13

1991-10-01

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 45, 560 48, 560 53, 560119, 562455, 562462, 2604105, 514533, 514534, 514824, 514540, C07C 976

Patent

active

050535250

ABSTRACT:
Mevinolin-like compounds in which the lactone is opened and the hydroxyl function produced thereby is replaced by an oxo function are potent HMG-CoA reductase inhibitors possessing one less asymmetric center.

REFERENCES:
Sato, A. et al., Chem. Pharm. Bull., 28(5), 1509-1525, 1980.

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