Oxiranes

Details Oxiranes Oxiranes

1984-07-30

1987-05-12

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549252, 549551, 549554, C07D40510, C07D3038, C07D30312

Patent

active

046651896

ABSTRACT:
There are described compounds of formula ##STR1## in which n is 0, 1 or 2, R.sup.1 is a hydrocarbyl group optionally substituted with an optionally substituted phenyl group and containing from 5 to 30 carbon atoms, R.sup.2 is optionally substituted phenyl or C.sub.1-10 alkyl optionally substituted by one or more substituents selected from optionally protected hydroxyl, optionally protected carboxyl, nitrile, optionally protected tetrazolyl, --COR.sup.6 where R.sup.6 is C.sub.1-4 alkyl, C.sub.1-4 alkoxy, an optionally protected amino acid residue or --NR.sub.2.sup.7 where each R.sup.7 is hydrogen or C.sub.1-4 alkyl, and --NHR.sup.8 where R.sup.8 is hydrogen, a protecting group, an optionally protected amino acid residue, C.sub.1-4 alkyl or --COR.sup.9 where R.sup.9 is C.sub.1-4 alkyl or C.sub.1-4 alkoxy, and R.sup.3, R.sup.4 and R.sup.5 are each selected from hydrogen, carboxyl, C.sub.2-5 alkoxycarbonyl, C.sub.1-4 alkyl, C.sub.1-4 alkoxy, hydroxyl, optionally protected tetrazolyl, halo, trifluoromethyl, nitrile, nitro and --CONR.sub.2.sup.10 where each R.sup.10 is hydrogen or C.sub.1-4 alkyl; and salts thereof. The compounds are leukotriene antagonists.

REFERENCES:
V. Prelog et al., Helv. Chim. Acta, 27, 1209 (1944) [Chemical Abstracts 40:848(8) supplied as an English Abstract].
G. A. Russell et al., J. Org. Chem., 31(9), 2854 (1966).
S. Kano et al., J. C. S. Chem. Comm., 785 (1978).
Eberbach et al., Chem. Ber., 114, 2979 (1981).
Eberbach et al., Tetrahedron Letters, (48), 4649 (1979).
Tamura et al., Synthesis, (10), 693 (1977).

Affiliated with

Also associated with

Rating

Oxiranes does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxiranes, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxiranes will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1803488