Oxindoles with anti-HIV activity

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S269000, C514S299000, C514S399000, C544S298000, C546S277100, C548S411000

Reexamination Certificate

active

10690802

ABSTRACT:
The present invention relates to inhibition of viruses, e.g., HIV using oxindoles and compounds related to oxindoles. The invention further relates to methods for identifying and using agents, including small molecule chemical compositions that inhibit HIV in a cell; as well as to methods of prophylaxis, and therapy related to HIV infection and related disease states such as AIDS.

REFERENCES:
patent: 6391907 (2002-05-01), Fensome et al.
patent: 6608068 (2003-08-01), Fensome et al.
patent: 57-102863 (1982-06-01), None
patent: WO 2001/077100 (2001-10-01), None
Database CAPLUS on STN, (Columbus, OH, USA), 126:185970, MOLDVAI, ‘Chemistry of indoles carrying a basic function. Part 3. Synthesis of spiro(cyclopropane-1, 3′[3H]indol}-2′(1H)-ones with antihypoxic effects’, abstract, Archiv der Pharmazie, (1996), vol. 329, No. 12, pp. 541-549. See, for example, the compound of CA Registry No. 187325-59-3.
Database CAPLUS on STN, (Columbus, OH, USA) 89:108935, Frank, ‘Spirocyclic 2-indolinones by 1,3-dipolar cycloaddition’, abstract, Justis Liebigs Annalen der Chemie (1978), vol. 5, pp. 717-725. See, for example, the compound of CA Registry No. 67503-06-4.

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