Oxindole derivative as feeding control agent

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S374000, C514S376000, C514S392000, C514S365000, C514S228200, C514S339000, C514S254090, C514S235200, C514S323000, C514S397000, C514S383000, C514S406000, C514S407000, C514S369000, C514S367000, C514S375000, C514S364000, C514S256000, C514S378000, C514S255050, C548S468000, C548S466000, C548S235000, C548S485000, C548S486000, C548S229000, C548S312100, C548S200000, C548S205000, C548S266400, C548S364700, C548S217000, C548S224000, C548S159000, C548S131000, C548S249000, C544S062000, C544S373000, C544S144000, C544S

Reexamination Certificate

active

07825155

ABSTRACT:
Disclosed is a compound represented by the formula (1) below, a prodrug thereof or a pharmaceutically acceptable salt of either, which is useful as a therapeutic, preventive or ameliorating agent for diabetes and the like.(In the formula, R3represents an optionally substituted carbamoyl group or the like; X represents a hydroxyl group or the like; W1and W2independently represent a single bond or methylene; R7and R8independently represent a hydrogen atom, an optionally substituted alkyl group or the like; and Ar represents an optionally substituted aryl group or the like.)

REFERENCES:
patent: 6576656 (2003-06-01), Tokunaga et al.
patent: 6939887 (2005-09-01), Okazaki et al.
patent: WO-2005/035498 (2005-04-01), None
Jordan, V. C. Nature Reviews: Drug Discovery, 2, 2003, pp. 205-213.
Dezaki et al. Pharmacology & Therapeutics 2008, 118, pp. 239-249.
Rautio et al. Nature Reviews Drug Discovery 2008, 7, pp. 255-270.
Wang et al. Drug Delivery: Principles and Applications, 2005 John Wiley & Sons, Inc. Publication, Section 8.3, pp. 136-137.
Smith, D. A. Current Opinion in Drug Discovery & Development 2007, 10, 550-559.
Testa, B. Current Opinion in Chemical Biology 2009, 13, pp. 338-344.

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