Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1992-09-30
1994-04-12
Rollins, John W.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514414, 514454, 514456, 514885, A61K 3140, A61K 3135
Patent
active
053026110
ABSTRACT:
Tetra- and pentacyclic oxindole alkaloids, in particular the alloisopteropodine, isomer A, a pentacyclic oxindole alkaloid, are suitable for the unspecific stimulation of the immunologic system, which has been proved by a substantial percental phagocytosis increase in the granulocytic test according to BRANDT (in vitro), a substantial percental increase of the CL-response in the chemiluminescence test (in vitro) and a high increase of the phagocytosis activity of tissue macrophages of the reticoloendothelial system in the carbon-clearence-test (CCT) according to BIOZZI.
REFERENCES:
patent: 3956491 (1976-05-01), Isaac
patent: 3990945 (1976-11-01), Huff
patent: 4940725 (1990-07-01), Keplinger et al.
Hemingway et al; Alkaloids from S. American Species of Uncaria (Rubiaceae), J. Pharm. Pharmac., vol. 26, Supp., p. 133, 1974.
Hemingway et al; Alkaloids from S. American Species of Uncaria (Rubiaceae), Chemical Abstracts, vol. 82, No. 21, May 26, 1975.
Chan et al; Alkaloids of Uncaria pteropoda, Isolation and Structures of Pteropodine and Isopteropodine, J. Chem. Society (C), vol. 24, pp. 2245-2249, 1966.
Ponglux et al; Alkaloids from the Leaves of Uncaria homomalla, Chemical Abstracts, vol. 87, p. 312, 1977.
Lleander et al; Three Isomeric Alkaloids from Uncaria perrottetii (Uncaria ferrea).
Matoshi et al., Effect of Indole Alkaloids from Gardneria genus on neuromuscular transmission in the rat limb in situ, Chemical Abstracts, vol. No. 84, 1976.
Matoshi et al.; Effects of Indole Alkaloids from Gardneria nutans Sieb. and Uncaria rhynchopylla Miq. on a guinea pig urinary bladder preparation in situ., Pharmacodynamics, vol. 91, 1979.
Chang et al., Study on the Mode of Hypotensive Action of Uncarine A, Pharmacodynamics, vol. 90, 1979.
Chang et al., Study on the antihypertensive action of uncarine A . . . , Pharmacodynamics, vol. 91, 1979.
Chang et al., Hypotensive Effect of rhynchophylla total alkaloids and rhynchophylline, Pharmacodynamics, vol. 92, 1980.
John Lust, The Herb Book, pp. 36-41, 1974.
Keplinger Dietmar
Keplinger Klaus
Keplinger Klaus
Rollins John W.
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