Oxindole alkaloids having properties stimulating the immunologic

Details Oxindole alkaloids having properties stimulating the immunologic Oxindole alkaloids having properties stimulating the immunologic

1988-05-16

1989-07-04

Rollins, John W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Conjugate or complex

514414, 514454, 514885, A61K 3578, A61K 3140, A61K 3135

Patent

active

048449016

ABSTRACT:
Tetra- and pentacyclic oxindole alkaloids, in particular the alloisopteropodine, isomer A, a pentacyclic oxindole alkaloid, are suitable for the unspecific stimulation of the immunologic system, which has been proved by a substantially percental phagocytosis increase in the granulocytic test according to BRANDT (in vitro), a substantial percental increase of the CL-response in the chemiluminescence test (in vitro) and a high increase of the phagocytosis activity of tissue macrophages of the reticoloendothelial system in the carbon-clearence-test (CCT) according to BIOZZI.

REFERENCES:
Hemingway et al., Chem. Abst. 82:135680k, 1975.

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