Oxime derivatives

Details Oxime derivatives Oxime derivatives

1992-11-05

1994-01-04

Springer, David B.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

546156, C07D40104, A61K 3147

Patent

active

052760413

ABSTRACT:
An oxime derivative of the formula: ##STR1## wherein R is a hydrogen atom or a C.sub.1-5 alkyl group, R.sub.1 is a hydrogen atom, a C.sub.1-5 alkyl group or a carboxyl-protecting group, R.sub.2 is a hydrogen atom, a halogen atom, a hydroxyl group or an amino group, R.sub.3 is a C.sub.3-7 cycloalkyl group, R.sub.4 is a hydrogen atom, a halogen atom or a C.sub.1-4 alkoxy group, each of R.sub.5 and R.sub.6 which may be the same or different, is a hydrogen atom or a C.sub.1-5 alkyl group, or R.sub.5 and R.sub.6 together represent a C.sub.2-4 alkylene group which forms together with the adjacent carbon atom a C.sub.3-5 ring, provided that when R.sub.2 is a hydrogen atom, R.sub.4 is a C.sub.1-4 alkoxy group, m is an integer of 0 or 1, and n is an integer of from 1 to 3; or its pharmaceutically acceptable salt.

REFERENCES:
Chemical Abstract, vol. 111, 1989, AN 153844p, p. 730, Nishitani Yasuhiro, et al., "Preparation of Quinolonecarboxylates and Analogs as Antibacterials".
Journal of Medicinal Chemistry, vol. 35, No. 8, Apr. 1992, pp. 1392-1398, C. S. Cooper, et al., "Preparation and In Vitro and In Vivo Evaluation of Quinolones with Selective Activity Against Gram-Positive Organisms".

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