Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing
Patent
1988-06-22
1990-09-25
Stone, Jacqueline
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
424 942, 424 944, 424 945, 514 44, 514 45, 514 46, 514 47, 514 48, 514 49, 514 50, 514 51, 514 52, 514866, A61K 3762, A61K 3152, A61K 31505
Patent
active
049592122
ABSTRACT:
A non-toxic, oxidizing-energizing composition suitable for use as an accelerator of the carbohydrate oxidative degradation metabolic process or the direct oxidation of glucose which consists essentially of, by weight, (A) 10% to 95% of flavine-adenine dinucloeotide coenzyme (FAD) and (B) 10% to 95% of at least one coenzyme or enzyme selected from the group consisting of flavine mononucleotide coenzyme (FM), ubiquinone coenzyme (UBQ), uridine 5'-triphosphate coenzyme (UTP), triphosphopyridine nucleotide coenzyme (TPN), diphosphopyridine nucleotide coenzyme (DPN), adenosine triphosphate coenzyme (ATP), uridine diphosphate glucose coenzyme (UDPG), guanosine 5'-triphosphate coenzyme (GTP), glucose oxidase enzyme (GOD) and mixtures thereof; and (C) 0% to less than 50% of an enzyme selected from the group consisting of fructosediphosphate aldolase, phosphofructokinase, hexokinase, glucokinase, glucose 6-phosphate dehydrogenase, glucose phosphate isomerase, d-glucose-phosphotransferase and mixtures thereof, said composition being effective to reduce the blood glucose concentration in a human body afflicted with diabetes. A further aspect of the invention comprises the combination of 1 mg. to 100 mg. of the foregoing oxidizing-energizing composition with a daily dosage of an antidiabetic drug in an amount effective to lower the blood glucose concentration in the human body, said combination yielding a blood glucose concentration which is lower than the concentration produced by the antidiabetic drug alone as well as a method of lowering the blood glucose concentration in the human body comprising the step of administering the oxidizing-energizing composition in combination with the daily dosage of an antidiabetic drug.
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Dumas Theodore
Spiliadis Apostol
Stancesco Alexandra
Miller Richard N.
Stone Jacqueline
Witz Jean C.
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