Oxidized heparin fractions and their use in inhibiting...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Reexamination Certificate

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C536S124000, C536S123100

Reexamination Certificate

active

08071569

ABSTRACT:
The present invention relates to a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 4,000 daltons, wherein from about 1% to about 100% of hydroxyl residues of the constituents are oxidized. The present invention also relates to methods of inhibiting angiogenesis and treating an angiogenesis-mediated disorder in a subject by administering a heparin fraction comprising constituents having molecular weights of from about 2,000 to about 30,000 daltons, wherein from about 1% to about 100% of hydroxyl residues of the constituents are oxidized. Another aspect of the present invention relates to compositions including the heparin fractions of the present invention.

REFERENCES:
patent: 4727063 (1988-02-01), Naggi et al.
patent: 4973580 (1990-11-01), Mascellani et al.
patent: 5092885 (1992-03-01), Yamada et al.
patent: 5112946 (1992-05-01), Maione
patent: 5192744 (1993-03-01), Bouck et al.
patent: 5202352 (1993-04-01), Okada et al.
patent: 5280016 (1994-01-01), Conrad et al.
patent: 5639725 (1997-06-01), O'Reilly et al.
patent: 5908837 (1999-06-01), Cohen et al.
patent: 6075013 (2000-06-01), Weitz et al.
patent: 6461665 (2002-10-01), Scholander
Office Action (Mail Date Jun. 27, 2005) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Final Office Action (Mail Date Mar. 8, 2006) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Office Action (Mail Date Oct. 1, 2007) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Final Office Action (Mail Date Apr. 9, 2008) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Office Action (Mail Date Oct. 27, 2008) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Decision on Appeal (Mail Date Sep. 29, 2010) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Decision on Reconsideration—Denied (Mail Date Dec. 21, 2010) for U.S. Appl. No. 10/667,216,—filed Sep. 19, 2003, First Named Inventor: Shaker A. Mousa; Confirmation No. 7027.
Definition of inhibit, Dictionary.com, http://dictionary.reference.com, accessed online on Apr. 2, 2008. Final Office Action (Mail Date Apr. 9, 2008) for U.S. Appl. No. 10/667,216.
Kerbel et al. Cancer and Metastasis Reviews, 20, 2001, p. 79-86.* Final Office Action (Mail Date Apr. 9, 2008) for U.S. Appl. No. 10/667,216.
Definition of Activated Partial Thromboplastin Time, Massacheusetts General Hospital Pathology Service, http://www.massgeneral.org, accessed on Oct. 20, 2008.* Office Action (Mail Date Oct. 27, 2008) for U.S. Appl. No. 10/667,216.
Definition of Heparin Antifactor Xa Assay, Massachusetts General Hospital Pathology Service, http://www.massgeneral.org, accessed online on Oct. 20, 2008.* Office Action (Mail Date Oct. 27, 2008) for U.S. Appl. No. 10/667,216.
Braswell, E., “Heparin: Molecular Weight and Degradation Studies,” Biochim. Biophys. Acta 185: 103-116 (1968).
Kosakai et al., “Isolation and Characterization of Sulfated Disaccharides from the Deamination Products of Porcine Heparin (α-Heparin) and Whale Heparin (ω-Heparin), and a Comparison of the Deamination Products,” J. Biochem. 83: 1567-1575 (1978).
Fransson et al., “Relationship Between Anticoagulant Activity of Heparin and Susceptibility to Periodate Oxidation,” FEBS Letters 97: 119-123 (1979).
Fujita et al. “Improvement of Treadmill Capacity and Collateral Circulation as a Result of Exercise with Heparin Pretreatment in Patients with Effort Angina,” Circulation 77: 1022-1029 (1988).
Rastinejad et al., “Regulation of the Activity of a New Inhibitor of Angiogenesis by a Cancer Suppressor Gene,” Cell 56: 345-355 (1989).
Moses et al., “Identification of an Inhibitor of Neovascularization from Cartilage,” Science 248: 1408-1410 (1990).
Blood et al., “Tumor Interactions with the Vasculature: Angiogenesis and Tumor Metastasis,” Biochim. Biophys. Acta 1032: 89-118 (1990).
Oikawa et al., “Angiogenic Factor of a Rat Mammary Tumor Cell Line (RMT-1) (I). Secretion of Two Distinct Angiogenic Factors into Serum-Free Conditioned Medium by RMT-1 Cells,” Cancer Letters 59: 57-66 (1991).
Buckley et al., “Enoxaparin: A Review of its Pharmacology and Clinical Applications in the Prevention and Treatment of Thromboembolic Disorders,” Drugs 44: 465-497 (1992).
Clapp et al., “The 16-Kilodalton N-Terminal Fragment of Human Prolactin Is a Potent Inhibitor of Angiogenesis,” Endocrinology 133: 1292-1299 (1993).
O'Reilly et al., “Angiostatin: A Novel Angiogenesis Inhibitor That Mediates the Suppression of Metastases,” Cell 79: 315-328 (1994).
Chen et al., “A Strategy to Discover Circulating Angiogenesis Inhibitors Generated by Human Tumors,” Cancer Research 55: 4230-4233 (1995).
Schnaper et al., “Plasminogen Activators Augment Endothelial Cell Organization In Vitro by Two Distinct Pathways,” Journal of Cellular Physiology 165: 107-118 (1995).
Larnkjaer et al., “Isolation and Characterization of Hexasaccharides Derived from Heparin. Analysis of HPLC and Elucidation of Structure by 1H NMR,” Carbohydrate Research 266: 37-52 (1995).
Strieter et al. “Interferon γ-Inducible Protein 10 (IP-10), a Member of the C-X-C Chemokine Family, is an Inhibitor of Angiogenesis,” Biochemical and Biophysical Research Communications 210: 51-57 (1995).
Angiolillo et al., “Human Interferon-inducible Protein 10 is a Potent Inhibitor of Angiogenesis in Vivo,” J. Experimental Medicine 182: 155-162 (1995).
Parangi et al., “Antiangiogenic Therapy of Transgenic Mice Impairs de novo Tumor Growth,” Proc. Natl. Acad. Sci. USA 93: 2002-2007 (1996).
Risau, “Mechanisms of Angiogenesis,” Nature 386: 671-674 (1997).
Mulloy et al., “Molecular Weight Measurements of Low Molecular Weight Heparins by Gel Permeation Chromatography,” Thrombosis and Haemostasis 4: 668-674 (1997).
Dickinson et al., “Enoxaparin Increases the Incidence of Postoperative Intracranial Hemorrhage when Initiated Preoperatively for Deep Venous Thrombosis Prophylaxis in Patients with Brain Tumors,” Neurosurgery 43: 1074-1081 (1998).
Linhardt et al., “Production and Chemical Processing of Low Molecular Weight Heparins,” Seminars in Thrombosis and Haemostasis 25: 5-16 (1999).
Kosir et al., “Degradation of Basement Membrane by Prostate Tumor Heparanase,” Journal of Surgical Research 81: 42-47 (1999).
Kakkar et al., “Antithrombotic Therapy in Cancer,” BMJ 318: 1571-1572 (1999).
Hettiarachchi et al., “Do Heparins Do More than Just Treat Thrombosis? The Influence of Heparins on Cancer Spread,” Thrombosis and Haemostasis 82: 947-952 (1999).
Mousa et al., “Comparative In Vitro Efficacy of Different Platelet Glycoprotein IIb/IIIa Antagonists on Platelet-Mediated Clot Strength Induced by Tissue Factor With Use of Thromboelastography,” Arterioscler. Thromb. Vasc. Biol. 20: 1162-1167 (2000).
Arkel, “Thrombosis and Cancer,” Seminars in Oncology 27: 362-374 (2000).
Zacharski et al., “Low-Molecular-Weight Heparin and Cancer,” Seminars in Thrombosis and Hemostasis 26: 69-77 (2000).
Eriksson et al., “Fondaparinux Compared with Enoxaparin for the Prevention of Venous Thromboembolism After Hip-Fracture Surgery,” N. Engl. J. Med. 345: 1298-1304 (2001).
Smorenburg et al., “The Complex Effects of Heparins on Cancer Progression and Metastasis in Experimental Studies,” Pharmacological Reviews 53: 93-105 (2001).
Mousa et al., “Comparison of the Effect of Different Platelet GPIIb/

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