Oxidized collagen formulations for use with non-compatible...

Details Oxidized collagen formulations for use with non-compatible... Oxidized collagen formulations for use with non-compatible...

2006-03-14

2006-03-14

Page, Thurman K. (Department: 1618)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Matrices

C424S484000, C530S350000, C530S356000

Reexamination Certificate

active

07011851

ABSTRACT:
Disclosed are oxidized collagen compositions wherein the thiomethyl group of one or more of the methionine residues of the collagen have been replaced with methylsulfoxy and/or methylsulfonyl groups.

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Bacakova, L. et al., “Oxidized Collagen Stimulates Proliferation of Vascular Smooth Muscle Cells,”Experimental and Molecular Pathology, 1997, 64: 185-194, Article No. MO972219, Academic Press.
Komsa-Penkova, R. et al., “Discrete reduction of type 1 collagen thermal stability upon oxidation,”Biophysical Chemistry, 1999, 83: 185-195, Elsevier Science B.V.
Lippman, R.D. et al., “Rapid In Vivo Quantification and Comparison of Hydroperoxides and Oxidized Collagen in Aging Mice, Rabbits and Man,”Experimental Gerontology, 1985, 20: 1-5, Pergamon Press Ltd.
Wells-Knecht, M.C. et al., “Age-dependent Increase inOrtho-Tyrosine and Methionine Sulfoxide in Human Skin Collagen is Not Accelerated in Diabetes,”J. Clin. Invest., 1997, 100(4): 839-846, American Society for Clinical Investigation, Inc.

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