Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-11-20
1989-07-04
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
546 77, C07J 7300, A61K 3158
Patent
active
048451045
ABSTRACT:
The compounds of formula (I) ##STR1## wherein R is selected from hydrogen, methyl or ethyl, and R.sup.1 is C.sub.1-12 straight or branched chain alkyl wherein one of the hydrogens is substituted by hydroxy, carboxylic acid or C.sub.1-4 alkyl ester, and A is --CH.sub.2 --CH.sub.2 or --CH.dbd.CH--, and pharmaceutical formulations of the above compounds are active as testosterone 5.alpha.-reductase inhibitors and thus are useful for treatment of acne, seborrhea, female hirsutism or benign prostatic hypertrophy.
REFERENCES:
patent: 4104285 (1978-08-01), Gallo-Torres
patent: 4191759 (1980-03-01), Johnston et al.
patent: 4220775 (1980-09-01), Rassmusson
patent: 4732897 (1988-03-01), Cainelli
patent: 4760071 (1988-07-01), Rasmusson
Rassmusson II, J. Med. Chem 29, 2298-2315.
Carlin Josephine R.
Rasmusson Gary H.
VandenHeuvel W. J. A.
Berch Mark L.
Caruso Charles M.
Merck & Co. , Inc.
Pfeiffer Hesna J.
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