Oxidative method for attachment of glycoproteins to surfaces of

Coating processes – Medical or dental purpose product; parts; subcombinations;... – Analysis – diagnosis – measuring – or testing product

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427 213, 427 224, 427 23, 427 231, B05D 310, A61L 3300, A61L 2700

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active

057284202

ABSTRACT:
A method for making a medical device having a glycoprotein immobilized on a substrate surface is provided. The method includes oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functional material; combining the aldehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and reacting the imine moiety with a reducing agent to form a secondary amine.

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