Oxidative metabolism in smooth muscle cells: methods and materia

Details Oxidative metabolism in smooth muscle cells: methods and materia Oxidative metabolism in smooth muscle cells: methods and materia

1998-10-19

2000-06-27

Krass, Frederick

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

436501, 436503, 436 62, 436 63, 436174, 436175, 436176, 436811, 436815, 436826, 436904, 435 11, 435375, 435405, 435973, 600562, 600573, 600584, A61K 4900, G01N 3318

Patent

active

060803851

ABSTRACT:
Disclosed are methods for measuring non-contractile oxidative metabolism in smooth muscle cells comprising providing a medium suitable for the support of oxidative metabolism, incubating a cell or tissue sample with a specimen from a patient, measuring a marker of oxidative metabolism in the incubate, and detecting an increase in oxidative metabolism which is not attributable to a contractile demand for ATP. Such an increase in oxidative metabolism will be indicative of the existence of an agent or combination of agents able to cause an increase in oxidative metabolism in smooth muscle cells, and thus provides means for diagnosing and monitoring various pathologies associated therewith.

REFERENCES:
patent: 4445500 (1984-05-01), Osterholm
Dissertation Abstracts International B Science and Engineering, vol. 42, No. 12, 1982, Washington DC USA, p. 4732 XP002039256, M.E. Rosenfeld et al.: Studies of oxidative metabolism in vascular smooth muscle.
FASB Journal, vol. 11, No. 3, Apr. 6, 1997, New Orleans LO USA, p. a59 XP002039152 G.J. Pyne et al.: "Vascular smooth muscle oxidation metabolism during vasospasm".
Chemical Abstracts 128:152332, "Peripheral Markers in Testing Pathophysiological Hypotheses and Diagnosing Alzheimer's Disease", Jan. 1998.

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