Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Hydrolase
Patent
1990-07-17
1993-05-04
Naff, David M.
Chemistry: molecular biology and microbiology
Enzyme , proenzyme; compositions thereof; process for...
Hydrolase
435198, 435209, 435183, 435188, 435201, C12N 950, C12N 926, C12N 920, C12N 942
Patent
active
052081583
ABSTRACT:
Novel chemically modified detergent enzymes are provided, wherein one or more methionines have been mutated into cysteines, said cysteines subsequently being chemically modified in order to confer the enzyme improved stability towards oxidative agents. A novel process for stabilizing detergent enzymes against oxidation is also provided. Furthermore, there are provided detergent compositions comprising these novel oxidation stable detergent enzymes.
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patent: 4874696 (1989-10-01), Payne et al.
Skaked et al., Rates of Thiol-Disulfide Interchange . . . Biochemistry, vol. 19, No. 18, pp. 4156-4166, 1980.
Estell et al., Engineering an Enzyme by Site-directed . . . , J. of Biol. Chem., vol. 260, No. 11, pp. 6518-6521, 1985.
Stauffer et al., vol. 24, No. 19, pp. 5333-5338, 1969.
Bech et al., Carlsberg Res. Commun., vol. 53, pp. 381-393 (1988).
Bech Lene M.
Branner Sven
Breddam Klaus
Groen Hanne
Lambiris Elias J.
Meller Michael V.
Naff David M.
Novo Nordisk A S
Zelson Steve T.
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