Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Patent
1990-04-09
1993-10-26
Ossanna, Nina
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
435 696, 530380, C07K 1300
Patent
active
052567702
ABSTRACT:
Novel soluble oxidation resistant thrombomodulin analogs are produced for various therapeutic and other uses, such as in thrombotic and vascular disease therapies. These analogs exhibit the characteristic therapeutic properties of native thrombomodulin, yet they are soluble and are not inactivated after they have been exposed to oxidants. Some of the analogs disclosed are multifunctional fusion proteins having both antithrombotic activity and some additional bioactivity.
REFERENCES:
patent: 4752585 (1988-06-01), Koths et al.
Suzuki et al. "Structure and expression of human thrombomodulin . . . " EMBO 6(7):1891-1897, Jul. 1987.
Esmon, N. L., et al., "Isolation of a Membrane-bound Cofactor for Thrombincatalyzed Activation of Protein C," J. Biol. Chem. 257:859-864 (1982).
Salem, H. H., et al., "Isolation and Characterization of Thrombomodulin from Human Placenta," J. Biol. Chem. 259:12246-12251.
Jackman, R. W., et al., "Characterization of a thrombomodulin cDNA reveals structural similarity to the low density lipoprotein receptor," PNAS 83:8834-8839 (1986).
Jackman, R. W., et al., "Human thrombomodulin gene is intron depleted: Nucleic acid sequences of the cDNA and gene predict protein structure and suggest sites of regulatory control," PNAS 84:6425-6429 (1987).
Wen, D., et al., "Human Thrombomodulin: Complete cDNA Sequence and Chromosome Localization of the Gene," Biochemistry 26:4350-4357 (1987).
Kurosawa, S., et al., "A 10-kDa Cyanogen Bromide Fragment from the Epidermal Growth Factor Homology Domain of Rabbit Thrombomodulin Contains the Primary Thrombin Binding Site," J. Biol. Chem. 263:5993-5996 (1988).
Zushi, M., et al., "The Last Three Consecutive Epidermal Growth Factor-like Structures of Human Thromobomodulin Comprise the Minimum Functional Domain for Protein C-activating Cofactor Activity and Anticoagulant Activity," J. Biol. Chem. 264(18):10351-10353 (1989).
Otani, H., et al., "In Vitro Study on Contribution of Oxidative Metabolism of Isolated Rabbit Hear Mitochondria to Myocardial Reperfusion Injury," Circulation Research 55(2):168-175 (1984).
Saldeen, T., "Clotting, Microembolism, and Inhibition of Fibrinolysis in Adult Respiratory Distress," (Symposium on Critical Illness) Surgical Clinics of N. America 63(2):285-304 (1983).
Idell, S., et al., "Local Abnormalities in Coagulation and Firbinolytic Pathways Predispose to Alveolar Fibrin Deposition in the Adult Respiratory Distress Syndrome," J. Clin. Invest. 84:695-705 (1989).
Clark, R. A. F., et al., "Endothelial Cell Regulation of Coagulation," The Molecular and Cellular Biology of Wound Repair, 4:87-114 (1988).
Ishii, H., et al., "Thrombomodulin Is Present in Human Plasma and Urine," J. Clin. Inv. 76:2178-2181 (1985).
Stearns, D. J., et al., "Residues 310-486 from the Epidermal Growth Factor Precusor Homology Domain of Thrombomodulin will Accelerate Protein C Activation," J. Biol. Chem. 264:3352-3356 (1989).
Morser, M. J., "Soluble Thrombomodulin Analogs," U.S. Ser. No. 312,141, filed FEb. 17, 1989 (abandoned).
Morser, M. J., "Soluble Thrombomodulin Analogs," U.S. Ser. No. 345,372, filed Apr 28, 1989 (pending).
Morser, M. J., et al., "Analogs of Thrombomodulin," U.S. Ser. No. 406,941, filed Sep. 13, 1989 (pending).
Glaser Charles B.
Light David R.
Morser Michael J.
Ossanna Nina
Schering AG
LandOfFree
Oxidation resistant thrombomodulin analogs does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxidation resistant thrombomodulin analogs, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxidation resistant thrombomodulin analogs will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-960328