Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Lymphokines – e.g. – interferons – interlukins – etc.
Patent
1988-05-10
1992-05-26
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Lymphokines, e.g., interferons, interlukins, etc.
530820, 530825, 435 6952, 435 6951, 435 695, 424 852, 424 851, 424 854, 424 855, 424 856, 424 857, C07K 1300, A61K 3700
Patent
active
051169436
ABSTRACT:
A biologically active reference therapeutic protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionyl residue susceptible to chloramine T or peroxide oxidation, wherein additional, non-susceptible methionyl residues are not so substituted. The oxidation-resistant mutein so produced is preferably a human mutein of interleukin-2 or interferon-.beta., and the conservative amino acid is most preferably alanine.
REFERENCES:
patent: 4738927 (1988-04-01), Taniguchi et al.
patent: 4760025 (1988-07-01), Estell et al.
patent: 4761375 (1988-08-01), Clark
Zoaller et al., NA, 10, 1982, pp. 64787-6500.
Wells et al., Gene 34, 1985, pp. 315-323.
Bauer et al., Gene 37, 1985, pp. 73-81.
Lee et al., Bochem Biophys Res. Comm 1988, pp. 807-813, vol. 156(2).
Leatherbarrow et al., Protein Engineering, vol. 1, 1986, pp. 7-16.
Halenbeck Robert F.
Koths Kirston E.
Mark David F.
Nitecti Danutee
Cetus Corporation
Draper Garnette D.
McGarrigle Philip L.
Murphy Lisabeth F.
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