Chemistry: molecular biology and microbiology – Micro-organism – per se ; compositions thereof; proces of... – Fungi
Patent
1986-08-05
1988-06-21
Tanenholtz, Alvin E.
Chemistry: molecular biology and microbiology
Micro-organism, per se ; compositions thereof; proces of...
Fungi
4351723, 435320, 435253, 536 27, 935 10, 935111, 530351, C12N 118, C12N 1500, C12N 100, C12N 120, C07H 1512, C07K 1300
Patent
active
047525851
ABSTRACT:
A biologically active reference therapeutic protein is protected against oxidation by a method involving substituting a conservative amino acid for each methionyl residue susceptible to chloramine T or peroxide oxidation, wherein additional, non-susceptible methionyl residues are not so substituted. The oxidation-resistant mutein so produced is preferably a human mutein of interleukin-2 or interferon-.beta., and the conservative amino acid is most preferably alanine.
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Halenbeck Robert F.
Innis Michael A.
Koths Kirston E.
Shaked Ze'Ev
Wang Alice M.
Cetus Corporation
Halluin Albert P.
Hasak Janet E.
Tanenholtz Alvin E.
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