Oxidation resistant indicator molecules

Chemistry: analytical and immunological testing – Heterocyclic carbon compound – Hetero-o

Reexamination Certificate

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C436S164000, C436S094000, C436S093000, C436S091000, C562S007000, C562S001000

Reexamination Certificate

active

07851225

ABSTRACT:
Compounds having enhanced oxidation stability are disclosed. The compounds have an aryl boronic acid residue having one or more electron withdrawing groups on the aromatic moiety which contains the boronic acid residue, such that the molecule has enhanced oxidation resistance as compared to a corresponding molecule without the one or more electron withdrawing groups.

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Jin et al., “Synthesis, Evaluation, and Computational Studies of Naphthalimide-Based Long-Wavelength Fluorescent Boronic Acid Reporters,” Chem. Eur. J. 2008, 14:2795-2804.
Kaur et al., “Substituent Effect on Anthracene-Based Bisboronic Acid Glucose Sensors,” Tetrahedron, 62 (2006), pp. 2583-2589.
Stones, D. et al., “Modular Solid-Phase Synthetic Approach to Optimize Structural and Electronic Properties of Oligoboronic Acid Receptors and Sensors for the Aqueous Recognition of Oligosaccharides,” Chem. Eur. J., 10 (2004), pp. 92-100.
International Search Report PCT/US2007/024704, May 9, 2008, 15 pages.

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