Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1999-04-01
2000-02-29
Dentz, Bernard
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D40504
Patent
active
060311010
ABSTRACT:
The present invention relates to an oxidation using sodium chlorite in the presence of a catalytic amount of TEMPO and sodium hypochlorite which converts the penultimate intermediate bearing a primary alcohol to the target endothelin antagonist compound of Formula I having a carboxylic acid ##STR1##
REFERENCES:
Anelli, P.L., et al., Journal of Organic Chemistry, vol. 52(12), pp. 2559-2562, 1987.
Mangzhu, Z., et al., Journal of Organic Chemistry, vol. 64(7), pp. 2564-2566, 1999.
Devine Paul N.
Mano Eiichi
Song Zhiguo
Tschaen David M.
Zhao Mangzu
Banyu Pharmaceuticals Co., Ltd
Camara Valerie J.
Daniel Mark R.
Dentz Bernard
Merck & Co. , Inc.
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