Oxidation process

Details Oxidation process Oxidation process

1995-12-12

2001-08-14

Shippen, Michael L. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C562S475000

Reexamination Certificate

active

06274776

ABSTRACT:

The present invention concerns the selective oxidation of 1,4-dichlorobenzene to 2,5-dichlorophenol.
U.S. Pat. No. 4,529,824 describes in general certain complexes of vanadium, niobium and tantalum and their use in hydroxylating aromatic hydrocarbons either as reactant or catalyst. Additionally, Moiseeva et al. Kinet. Katal 29(4), pp 970-4(1988) describe oxidation of benzene with vanadium compounds albeit not selectively for phenol (oxidation proceeds at least in part to quinone).
It has now surprisingly been found that oxidation of 1,4-dichlorobenzene to 2,5-dichlorophenol can be effected with improved yield and selectivity when carried out in the presence of certain metal derivatives and in the presence of an &agr;-hydroxy-, dibasic-, tribasic- or sulfonic acid.
The present invention therefore provides a process for the preparation of 2,5-dichlorophenol which comprises selectively oxidizing 1,4-dichlorobenzene using a peroxo-, hydroperoxo-, superoxo- or alkylperoxo-metal species wherein said metal is selected from scandium, yttrium, lanthanum, titanium, zirconium, hafnium, vanadium, niobium, tantalum, chromium, molybdenum, tungsten, manganese, rhenium, iron, ruthenium, selenium, tellurium, osmium, cobalt, rhodium, iridium, nickel, palladium, platinum, copper, silver, zinc, aluminum, gallium, indium, tin, cerium, praseodymium, neodymium, samarium, europium, gadolinium, terbium, dysprosium, holmium, erbium, thulium, ytterbium, lutetium, and uranium or mixtures thereof in the presence of an acid selected from an &agr;-hydroxy-, dibasic-, tribasic- or sulfonic acid or mixtures thereof. The preferred metal is vanadium.
The reaction may be improved by optional addition of a second acid component selected from formic acid or an alkanoic acid.
The active metal species may be prepared by using an oxidation agent. Suitable oxidation agents included organic peroxides such as peroxycarboxylic acids, RCO
3
H, alkyl hydroperoxides, ROOH, and dialkylperoxides, ROOR, for example peroxyacetic acid, peroxybenzoic acid, peroxyformic acid, t-butyl hydroperoxide, and di-t-butylperoxide and inorganic peroxides such as peroxydisulfuric acid and peroxoborates. The preferred peroxide for use in the invention however, is hydrogen peroxide, especially in aqueous solution. The present process can be carried out at dilutions of 3% to 90% with efficient utilization of H
2
O
2
and improved yields. However, ca 20-70% e.g. 35-70% aqueous H
2
O
2
is preferred. The proportions of H
2
O
2
to 1,4-dichlorobenzene may vary between 0.1 and 5, e.g. between 0.25 and 3. It has been determined that particularly high efficiency may be achieved using approximately equimolar amounts of H
2
O
2
and 1,4-dichlorobenzene, e.g. ca 0.9 to ca 1.1 molar proportion of H
2
O
2
per mole of 1,4-dichlorobenzene.
The oxidizing agent is preferably added slowly e.g. dropwise or subsurface to the other reactants with thorough and continuous mixing.
The reaction may be carried out by continuous feed of the reactants or as a batch process.
When hydrogen peroxide is employed addition of small amounts of stabilizers may be of benefit to the reaction in some cases. Examples of such stabilizers include zinc salts, phosphates, pyrophosphates, ascorbic acid, 2,6-di-tert-butyl-4-methylphenol, 5-tert-butyl-4-hydroxy-2-methylphenylsulfide, 8-hydroxy-quinoline or tin compounds such as stannic oxide.
Alternatively use of highly stabilized commercial grades of hydrogen peroxide such as Super D H
2
O
2
(FMC, Rockland, Me.) or Albone 35CG or 50CG (DuPont Co., Wilmington, Del.) can give superior yield in some conditions.
The peroxo-, hydroperoxo-, superoxo- or alkylperoxo-metal species may be and preferably is generated in situ from the desired metal either as pure metal or in the form of a suitable oxide, salt, acetoacetonate or other derivative.
The metal may alternatively be used in the form of a polyoxoanion such as, in the case of vanadium, decavanadate [V
10
O
28
]
6−
which is generated in situ by employing suitable salts such as e.g. sodium ammonium decavanadate. Keggin type mixed addenda heteropolyanions containing vanadium atoms of the general formula [XVnM
12
−nO
40
]
(3+m)−
where X═P or Si, M═Mo or W, and n=1 to 3, are also effective. (When X═P, m=n; and when X═Si, m=n+1). Other useful Keggin types include molybdo-vanado-tungstophosphoric heteropolyanions of the general formula [PMo
3−n
VnW
9
O
40
]
(3+n)−
.
Suitable metal forms include oxides, acetoacetonates, alkoxymetal derivatives, sulfates, nitrates, halides, oxyhalides, alkylthiocarbamates or metalates with other cations, (e.g. ammonium metavanadate NH
4
VO
3
or polyoxovanadate salts such as sodium ammonium decavanadate).
Preferred metals include molybdenum, titanium, vanadium, tungsten, rhenium, selenium, niobium, tantalum and tellurium with vanadium being particularly preferred.
Preferred metal forms include oxides, acetoacetonates, alkoxymetal oxides and polyoxoanionic salts such as vanadium (V) oxide (V
2
O
5
) and sodium ammonium decavanadate.
A discussion of peroxo-, hydroperoxo-, superoxo- and alkylperoxo-metal species can be found in Conte et al. in Organic Peroxides Ed. W. Ando, John Wiley & Sons (1992) (pp 559-598).
General descriptions of polyoxoanions and heteropolyanions can be found as follows: Pope, Isopolyanions and Heteropolyanions in Comprehensive Coordination Chemistry (eds. Wilkinson, Gillard & McCleverty), 1987, Ch. 38; Day et al., Science v. 228 n 4699 pp 533-541; Jeannin et al., Pure and Applied Chem. v 59 n 11, pp 1529-1548, 1987; and Pope, Heteropoly and Isopoly Oxometalates, Springer Verlag 1983; Neumann and de la Vega, J. Mol. Catal., v 84, pp 93-108 (1993); Ono, Perspectives in Catalysis (Eds J. M. Thomas and K. I. Zamaraiev), 1992, pp 431-464, Blackwell Scientific Publ., Oxford, the contents of which in this respect are incorporated by reference.
Discussion of hydroperoxide oxidising agents and metal derivatives may also be found in U.S. Pat. Nos. 3,350,422; 3,351,635; 3,360,584; 3,360,585; and 3,662,006.
The metal derivatives can be present in amount equivalent to between 0.001 and 100 mol % of metal. Preferably catalytic amounts of 0.05 to 15 mol % are employed.
The metal derivative may be recycled and regenerated. For example when an oxide such as vanadium (V) oxide is used the spent catalyst can be heated in air (cf Polish Patent PL 73-165695; C.A. 87,91418) or treated with hydrogen peroxide. Alternatively the catalyst may be recovered and recycled as is.
The acid component of the process according to the invention is selected from an &agr;-hydroxy-, dibasic-, tribasic- or sulfonic acid. Examples of such acids include oxalic, malonic, 1,2,4-butanetricarboxylic, methanesulfonic, citric, lactic, 3-phenyllactic, 3-chlorolactic, tartaric, glycolic, a phosphoric acid (e.g. phosphoric acid itself, pyrophosphoric acid, polyphosphoric acid and functional equivalents, e.g. phosphorous pentoxide alone or with methanesulfonic acid; cf. Eaton et al. J. Org. Chem., v 38, n 23, pp 4071-73 (1973)), alkylphosphonic or arylphosphonic acids, e.g. methyl phosphonic, 3-phosphonopropionic, phosphonoacetic, mandelic, glyceric, malic, gluconic, 2,6-pyridinedicarboxylic, sulfuric, o-, m- or p-phthalic and mixtures thereof. In some cases salt forms may be employed e.g. sodium phosphate.
Such acids may be employed where appropriate in various isomeric forms and racemic mixtures thereof. Particularly preferred acids are selected from oxalic, a phosphoric acid and mixtures thereof. The following articles discuss the interaction of vanadium salts with such acids. Caldeira et al. J. Mol. Struct., v. 174 pp 461-466 (1988); Gil, Pure & Appl. Chem., v 61 n 5, pp 841-848 (1989); Lee et al., Bull Korean Chem. Soc., v 14, n 5, pp 557-561 (1993); Bhattacharjee et al., Can. J. Chem., v 70, pp 2245-8, (1992); Vuletic et al., J.C.S. Dalton Transactions (D.T.), pp 1137-41, 1973; Begin et al., Inorg. Chem., v 14, n 8, pp 1785-90, (1975); Schwendt et al., Z. anorg. allg. Ch

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