Single-crystal – oriented-crystal – and epitaxy growth processes; – Processes of growth from liquid or supercritical state – Having growth from a solution comprising a solvent which is...
Reexamination Certificate
2005-02-01
2005-02-01
Kunemund, Robert (Department: 1765)
Single-crystal, oriented-crystal, and epitaxy growth processes;
Processes of growth from liquid or supercritical state
Having growth from a solution comprising a solvent which is...
C117S069000, C117S937000, C117S939000, C424S451000, C424S464000, C514S618000
Reexamination Certificate
active
06849120
ABSTRACT:
The present invention provides an improved process for preparing modafinil, whereby it may be isolated in high purity by a single crystallization. The process produces modafinil free of sulphone products of over-oxidation and other byproducts. The invention further provides new crystalline Forms II-VI of modafinil and processes for preparing them. Each of the new forms is differentiated by a unique powder X-ray diffraction pattern. The invention further provides pharmaceutical compositions containing novel modafinil Forms II-IV and VI.
REFERENCES:
patent: 4177290 (1979-12-01), Lafon
patent: 4927855 (1990-05-01), Lafon
patent: 5618845 (1997-04-01), Grebow et al.
patent: 5719168 (1998-02-01), Laurent
patent: 6348500 (2002-02-01), Fu
patent: 6465519 (2002-10-01), Fu
patent: 20020183552 (2002-12-01), Naddaka et al.
patent: 0 258 134 (1987-08-01), None
patent: 1260501 (2002-11-01), None
Josef Drabowicz et al. “A Convenient Procedure for the Oxidation of Sterically Hindered Sulfides to Sulfoxides” Synthesis—Journal of Synthetic Organic Chemistry—Oct. 1990.
Jerry March “Reactions, Mechanisms, and Structure” Advanced Organic Chemistry, Fourth Edition.
Th. Becue et al. “Confirmation of the Structure of by-products in the synthesis of Modafinil by liquid chromatography-mass spectrometry” Journal of Chromatography, 557 (1991) 489-494.
Renault J. Guillon et al “Synthesis and CNS Activity of New 3-Amino-3-arylpropionic Acid Derivatives”, Pharm. Pharmacol. Commun. 1999, 5:217-223.
Aronhime Judith
Ceausu Arina
Gershon Neomi
Lieberman Anita
Singer Claude
Kenyon & Kenyon
Teva Pharmaceutical Industries Ltd.
LandOfFree
Oxidation method for preparing highly pure modafinil,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxidation method for preparing highly pure modafinil,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxidation method for preparing highly pure modafinil,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3464816