Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Reexamination Certificate
2007-03-06
2007-03-06
Prouty, Rebecca E. (Department: 1652)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
C435S189000, C435S069100, C435S320100, C536S023200
Reexamination Certificate
active
10509622
ABSTRACT:
There is disclosed an oxidase gene useful for the diagnosis of RA and the screening of a substance for the treatment of RA and/or a substance for the treatment of osteoarthritis. Also, an inspection method useful as a diagnosis method for RA is disclosed. Additionally, there is disclosed a method for screening a substance for the treatment of RA and/or a substance for the treatment of osteoarthritis, using the aforementioned novel oxidase gene. Also disclosed is a method for producing a pharmaceutical composition for the treatment of RA and/or the treatment of osteoarthritis which comprises an inhibitor of the aforementioned oxidase, which is obtainable by the aforementioned screening method, as an active ingredient.
REFERENCES:
patent: WO 00/28031 (2000-05-01), None
patent: WO 01/96390 (2001-12-01), None
patent: WO 02/06515 (2002-01-01), None
patent: WO 02/081703 (2002-10-01), None
patent: WO 02/103028 (2002-12-01), None
Banfi et al., “Two novel proteins activate superoxide generation by the NADPH oxidase NOX1”, J. Biol. Chem., 278(6): 3510-3513, Feb. 7, 2003.
Botond Banfi et al., “A Mammalian H+ Channel Generated Through Alternative Splicing of the NADPH Oxidase Homolog NOH-1”, SCIENCE (2000), vol. 287, pp. 138-142.
Young-Ah Suh et al., “Cell transporation by the superoxide-generating oxidase MX1”, NATURE (1999), vol. 401, pp. 79-82.
Elena A. Ostrakhovitch et al., “Oxidative stress in rheumatoid arthritis leukocytes: suppression by rutin and other antioxidants and chelators”, Biochemical Pharmacology (2001), vol. 62, No. 6, pp. 743-746.
Dan Sorescu et al., “Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis”, (2002) Circulation, vol. 105, No. 12, pp. 1429-1435.
Supplementary Partial European Search Report dated Aug. 9, 2005.
Astellas Pharma Inc.
Prouty Rebecca E.
Sughrue & Mion, PLLC
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