Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1999-11-30
Wax, Robert A.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540145, 252399, 25240023, 435189, 4352523, 4353201, A01N 5502, C07B 4700, C09K 1504, C09K 1532
Patent
active
059943394
ABSTRACT:
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating intra- and extracellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
REFERENCES:
patent: 4614723 (1986-09-01), Schmidt
patent: 4746735 (1988-05-01), Kruper, Jr. et al.
patent: 4758422 (1988-07-01), Quay
patent: 4837221 (1989-06-01), Bonnett
patent: 4851403 (1989-07-01), Picker et al.
patent: 4895719 (1990-01-01), Radhakrishnam
patent: 4963367 (1990-10-01), Ecanow
patent: 5051337 (1991-09-01), Sakoda et al.
patent: 5130245 (1992-07-01), Marklund et al.
patent: 5162519 (1992-11-01), Bonnett
patent: 5169630 (1992-12-01), Okaya et al.
patent: 5171680 (1992-12-01), Mullenbach et al.
patent: 5202317 (1993-04-01), Bruice
patent: 5217966 (1993-06-01), Bruice
patent: 5223538 (1993-06-01), Fridovich
patent: 5227405 (1993-07-01), Fridovich
patent: 5236914 (1993-08-01), Meunier
patent: 5236915 (1993-08-01), Fiel
patent: 5248603 (1993-09-01), Marklund et al.
patent: 5262532 (1993-11-01), Tweedle et al.
patent: 5284647 (1994-02-01), Niedballa
patent: 5366729 (1994-11-01), Marklund et al.
patent: 5472691 (1995-12-01), Marklund et al.
patent: 5493017 (1996-02-01), Therien et al.
Inoue et al, "Expression of a Hybrid Cu/Zn-type Superoxide . . . ," J. Bio. Chem., vol. 26,6 No. 25, pp. 16409-16414 (1991).
Day et al, "Manganic Porphyrins Posses Catalase Activity . . . , " Arch. Biochem. Biophys., vol. 347, No. 2, pp. 256-262 (1997).
Tsan, M-F., "Superoxide Dismutase and Pulmonary Oxygen Toxicity," XP-002074505, pp. 286-290.
Boissinot et al, "Rational Design and Expressionof A Heparin-Targeted Human Superoxide Dismutase", Biochemical and Biophysical Research Communication 190(1):250-256 (1993-.
Oury et al, "Cold-induced Brain Edema in Mice", The Journal of Biological Chemistry 268(21):15394-15398 (1993).
Oury et al, "Extracellular superoxide dismutase, nitric oxide, and central nervous system O.sub.2 toxicity", Proc. Natl. Acad. Sci. USA 89:9715-9719 (1992).
Oury et al, "Establishment of Transgenic Mice Expressing Human Extracellular Superoxide Dismutase", American Review of Respiratory Disease 143(4):A515 (1991), International Conference Supplement Abstracts -No. 236.
Oury et al, "Transgenic Mice Superexpressing Human Extracellular Superoxide Dismutase Show Increased Resistance to Cold-induced Brain Edema, But are Mor Susceptible to Hyperbaric Oxgyen", American Review of Respiratory Disease 145(4):A713 (1992), International Conference Supplement Abstracts -No. 211.
Oury et al, "Immunocytochemical Localization of Extracellular Superoxide Dismutase in Human Lung", American Review of Respiratory Disease 147(4):A713 (1993) International Conference Supplement Abstracts -No. 246.
Oury, Tim D., "Extracellular Superoxide Dismutase and Nitric Oxide: Transgenic and Immunocytochemical Studies", Dissertation submiited in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pathology in the Graduate School of Duke University (Jun. 17, 1993).
Naruta et al. (1991). J. Am. Chem. Soc. 113:3595-3596, 1991.
Leondiadis et al. (1989). J. Org. Chem. 54: 6135-6138, 1989.
Stralin et al, "Effects of Oxidative Stress on Expression of Extracellular Superoxide Dismutase, CuZn-Superoxide Fibroblast", Biochem. J. 298:347-352 (1994).
Folz et al, "Extracellular Superoxide Dismutase (SOD3): Tissue-Specific Expression, Genomic Characterization, and Computer-Assisted Sequecne Analysis of the Human EC SOD Gene", Genomics 22:162-171 (1994).
Clyde et al, "Distributin of Manganese Superoxide Dismutase mRNA in Normal and Hyperoxic Rat Lung", American Journal of Respiratory Cell and Molecular Biology 8:530-537 (1993).
Wolberg et al, Electrcical and Electron Paramagnetic Resonance Studies of Metalloporphyrins and Thier Electrochemical Oxidation Products:, Journal of the American Chemcial Society 92(10):2982-2990 (1970).
Pasternack et al, "Superoxide Dismutase Activities of an Iron Porphyrin and Other Iron Complexes", Journal of the American Chemical Society 101(4):1026-1031 (1979).
Winkelman, James, "The Distribution of Tetraphenylporphinesulfonate in the Tumor-bearing Rat", Cancer Research 22:589-596 (162).
Moisy et al, "Catalytic Oxidation of 2,6-Terbutylphenol by Molecular Oxygen Elecroassisted by Poly(Pyrrole-Manganese-Porphyrin)", New J. Chem. 13:511-514 (1989).
Malinski et al, "Characterization of Conductive Polymeric Nickel(II) Tetrakis(3-methoxy-4-hydroxy-phenyl)Porphrin as an Anodic Material for Electrocatalysis", J. Electroche. Soc. 138(7):2008-2015 (1991).
Weinraub et al, "Chemical properties of water-soluble porphyrins. 5. Reactions of some manganese (III) porphyrins with the superoxide and other reducing radicals", Int. J. Radiat. Biol. 50(4):649-658 (1986) (Abs).
Fajer et al, ".pi.-Cation Radicals and Dications of Metalloporphyrins", Journal of the American Chemical Society 92(11):3451-3459 (1970).
Pasternack et al, "Aggregation of Nickel(II), Coopwer (II), and Zinc(II) Derivatives of Water-Soluble Porphyrins", Inorganic Chemistry 12(11):2606-2610 (1973).
Datta-Gupta et al, "Synthetic Porphyrins. I. Synthesis and Spectra of Some para-Substituted meso-Tetraphenylporphines (1)", J. Heterocycl. Chem. 3:495-502 (1966).
Harriman et al, "Photochemistry of Manganese Porphyrins Part 2 -Photoreduction", pp. 1543-1552.
Longo et al, "The Synthesis and Som e Physical Properties of ms-Tetra(pentafluorophyenyl)-porphin and ms-Tetraphenylporphines(1)", Notes 6:927-931 (1969).
Barnitz et al, Reactions of Fe.sup.III (meso-.alpha., .alpha., .alpha.-tetrakis[O-[N-methylisonicotinamido)phenyl]porphyrin).sup.5+ and Fe.sup.III (meso-tetrakis[N-methylpyridinium-4-yl]porphyrin).sup.5+ with NC; Co.sub.2 ; and O.sub.2.sup.II, Inorg. Chem. 32:941-947 (1993).
Pasternack et al, "On the Aggregation of Meso-Substituted Water-Soluble Porphyrins", Journal of American Chemical Society 94(13):4511-4517 (1972).
Data-Gupta et al, "Synthetic Porphyrins II Preparation and Spectra of Some Metal Chelates of para", Journal of Substituted-mesa-Tetrapheynylporphines, Journal of Pharmaceutical Science 57(2):300-304 (1968).
Gosh, "Substituent Effects on Valence Ionization Potentials of Free Base Porphyrins: Local Density Functional Calculations and Their Relevance to Electrochemical and Photoelectron Spectroscopic Studies", J. Am. Chem. Soc. 117:4691-4699 (1995).
De Peretti et al, "Imidazol[2,1-b]benzoxazole-3-acetamide derivatives, their preparation, and their therapeutic use", Chemical Abstracts 121;1016, Abstract No. 121:200896u.
Oberley et al, "Anticancer activity of metal compounds with superoxide dismutase activity", Agents and Actions 15(5/6):535-538 (1984).
Collman et al, "Synthesis of Face to Face Porphyrin Dimers Linked by 5,15-Substituents: Potential Binuclear Multielectron Redox Catalysts", J. Am. Chem. Soc. 103:516-533 (1981).
Gassman et al, "Electronic Effects of Peripheral Sustitiuents in Porphyrins: X-ray Photoelctron Spectroscopy and ab Initio Self-Consistent Field Calculations", J. Am. Chem. Soc. 114:9990-10000 (1992).
Bishop et al, "The Reactin of Thiomides with Phosphorus Ylides", J. Org. Chem. 56:5079-5091 (1991).
Picker et al, "Cobalt(III) complexes of water soluble synthetic meso-substituted porphyrins as radiation sensitizers for oxic and hypoxic tumor cells", 8-Radiation 112:405 (1990) Abstract No. 112:73026d.
McCord et al, "Superoxide Dismutase-An Enzymic Function for Erythrocuprein", Biochemistry 492, p. 346.
McCord et al, "Superoxide Dismutase An Enzymic Function for Erythrocuprein (Hemocuprein)", The Journal of Biological Chemistry 244(22):6049-6055 (1969).
Crapo et al, "The Failure of Aeorsolized Superoxide Dismutase to Modify Pulmonary Oxygen Toxicity", American Review of Respiratory Disease 115:1027-1033 (1977).
Joester et al, "Superoxide Dismutase Activity of Cu.sup.2+ -Amino Acid Chelates", FEBS Letters 25(1):25-28 (197.
Brigelius et al, "Superoxide Dismutase Activity of Low Molecular Weight Cu2+-Chelates Stu
Crapo James D.
Day Brian J.
Folz Rodney J.
Freeman Bruce A.
Fridovich Irwin
Duke University
Saidha Tekchand
University of Alabama at Birmingham Research Foundation
Wax Robert A.
LandOfFree
Oxidant scavengers does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Oxidant scavengers, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxidant scavengers will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1672784