Oxetanones and process for their production

Details Oxetanones and process for their production Oxetanones and process for their production

1989-08-08

1991-01-08

Hollrah, Glennon H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30512

Patent

active

049837460

ABSTRACT:
The invention is directed to a process for the manufacture of pancreatic lipase-inhibiting oxetanone ethyl esters of the formula ##STR1## wherein X is undecyl or 2Z,5Z-undecadienyl; C.sub.6 is n-hexyl; Y is isobutyl and Z is formyl or Y is carbamoylmethyl and Z is acetyl;
which process comprises esterifying the corresponding oxetanone ethanols, or hydrogenating the 3-undecenyl group in corresponding oxetanone ethyl ester starting materials to the undecyl group X, or N-formylating or N-acetylating corresponding primary amines.

REFERENCES:
Mitsunobo, Oyo, Synthesis, No. 1, (Jan. 1981), pp. 1-3.

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