Oxepane isomers of rapamycin useful as immunosuppressive agents

Details Oxepane isomers of rapamycin useful as immunosuppressive agents Oxepane isomers of rapamycin useful as immunosuppressive agents

1992-01-16

1993-06-22

Bond, Robert T.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

C07D49816, A61K 31395

Patent

active

052217400

ABSTRACT:
A derivative of rapamycin of general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, acyl, sulfonyl or alkyl or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.

REFERENCES:
patent: 3929992 (1975-12-01), Sechal et al.
patent: 5091389 (1992-02-01), Ondeyka et al.
patent: 5100899 (1992-03-01), Calne
Can. J. Physiol. Pharmacol. 55,48 (1977).

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