Oxepane isomers of rapamycin useful as immunosuppressive agents

Details Oxepane isomers of rapamycin useful as immunosuppressive agents Oxepane isomers of rapamycin useful as immunosuppressive agents

1993-03-18

1994-09-06

Goldberg, Jerome D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

A61K 3144

Patent

active

053448332

ABSTRACT:
A derivative of rapamycin of general formula (I) ##STR1## wherein R.sup.1 and R.sup.2 are selected from the group consisting of hydrogen, acyl, sulfonyl or alkyl or a pharmaceutically acceptable salt thereof, which is by virtue of its immunosuppressive activity is useful in treating transplantation rejection host vs. graft disease, autoimmune diseases, and diseases of inflammation.

REFERENCES:
patent: 3929992 (1975-12-01), Sechal et al.
patent: 5091389 (1992-02-01), Ondeyka et al.
patent: 5100899 (1992-03-01), Calne
Can. J. Physiol., Pharmacol. 55,48 (1977).

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