Oxazopinyl terminated alkylamino ethynyl alanine amino diol comp

Details Oxazopinyl terminated alkylamino ethynyl alanine amino diol comp Oxazopinyl terminated alkylamino ethynyl alanine amino diol comp

1993-12-16

1995-05-02

Brust, Joseph Paul

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540488, 540544, A61K 31535, C07D26710

Patent

active

054119537

ABSTRACT:
Compounds characterized generally as oxazopinyl-terminated alkylamino ethynyl alanine amino diol derivatives are useful as renin inhibitors for the treatment of hypertension. Compounds of particular interest are those of Formula I ##STR1## wherein A is selected from CO and SO.sub.2 ; wherein X is selected from oxygen atom and methylene; wherein B is an oxazopinyl group; wherein R.sub.1 is selected from hydrido, methyl, ethyl, isopropyl and n-propyl; wherein R.sub.2 is phenylmethyl; wherein each of R.sub.3 and R.sub.5 is hydrido; wherein R.sub.4 is selected from

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