Oxazolyl-pyrazole derivatives as kinase inhibitors

Details Oxazolyl-pyrazole derivatives as kinase inhibitors Oxazolyl-pyrazole derivatives as kinase inhibitors

2006-09-12

2006-09-12

Saeed, Kamal A. (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S338000, C514S375000, C548S217000, C546S271700, C546S115000, C546S270400

Reexamination Certificate

active

07105535

ABSTRACT:
Compounds which are oxazolyl-pyrazole derivatives, as defined in the specification, and pharmaceutically acceptable salts thereof; are useful in the treatment of diseases caused by and/or associated with an altered protein kinase activity such as cancer, cell proliferative disorders, viral infections, autoimmune diseases and neurodegenerative disorders.

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Meanwell, et al. “Nonprostaniod Prostacyclin Mimetics. 5. Structure-Activity Relationsips Associated with [3-[4-(4,5-Diphenyl-2-oxazolyl)-5-oxazolyl]phenoxy]acetic Acid,” Journal of Medicinal Chemistry, pp. 3884-3903, (1993).
Mustafa M. El-Abadelah, Thienopyridinone antibacterials: Synthesis and antibacterial activity of some 7-aryl-2-chloro-4,7-dihydro-4-oxothieno[2,3-b]pyridine-5-carboxylic acids, Eur. J. Med. Chem., 33, 33-42, (1998).
Tomoko Hosoi, Evidence for cdk5 as a Major Activity Phosphorylating Tau Protein in Porcine Brain Extract, J. Biochem., 117, 741-749, (1995).

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