Oxazolo-pyrimidine derivatives

Details Oxazolo-pyrimidine derivatives Oxazolo-pyrimidine derivatives

1987-12-15

1990-08-28

Rizzo, Nicholas S.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544276, 544277, C07D23900

Patent

active

049526936

ABSTRACT:
Novel purine derivatives, particularly novel guanines and hypoxanthines, are described as agents for treating autoimmune diseases. Also novel methods of manufacture for the derivatives, pharmaceutical compositions thereof, and methods of use therefor are the invention.

REFERENCES:
patent: 4411690 (1983-10-01), Tseng
D. S. Shewach et al., "Potentiation of 2'-deoxyguanosine cytotoxicity by a novel inhibitor of purine nucleoside phosphorylase, 8-amino-9-benzylguanine", Cancer Research 46, 519-523 (Feb. 1986).
Discussion at 16th Annual Graduate Student Meeting in Med. Chem. at U. of M., Ann Arbor, MI, "8 Amino-9-Benzylguanine".
Bio Chem. Pharm., 31, 163-171, (1982).
J. Am. Chem. Soc. 81, 3046-3051 (1959).
J. Het. Chem., 21, 1245-1246 (1984).
Heterocycles, vol. 22, No. 8, 1984, pp. 1789-1790.
Heterocycles, vol. 22, No. 11, 1984, pp. 2439-2441.

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