Oxazolidinone derivatives

Details Oxazolidinone derivatives Oxazolidinone derivatives

2004-12-17

2010-10-19

Morris, Patricia L (Department: 1625)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C546S271400

Reexamination Certificate

active

07816379

ABSTRACT:
The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such asBacteroidesand Clostridia, and acid-resistant microorganisms such asMycobacterium tuberculosisandMycobacterium avium. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

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