Oxazolidinone and/or isoxazoline as antibacterial agents

Details Oxazolidinone and/or isoxazoline as antibacterial agents Oxazolidinone and/or isoxazoline as antibacterial agents

2008-07-08

2008-07-08

McKane, Joseph (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C514S376000, C514S378000, C548S215000, C548S225000, C548S240000

Reexamination Certificate

active

10489266

ABSTRACT:
Compounds of the formula (I), or a pharmaceutically-acceptable salt, or an in-vivo-hydrolysable ester thereof,and compounds as shown in (I) wherein C is for examplewherein A and B are independently selected fromR2a to R3b are independently selected from hydrogen and fluorine;R1a and R1b are independently selected from, for example, hydroxy, —NHC(═W)R4,wherein W is O or S; R4is, for example, hydrogen, amino, (1-4C)alkyl; HET-1 is, for example, a C-linked 5-membered heteroaryl ring; HET-2 is, for example, an N-linked 5-membered, fully or partially unsaturated heterocyclic ring; are useful as antibacterial agents; and processes for their manufacture and pharmaceutical compositions containing them are described.

REFERENCES:
patent: 5043443 (1991-08-01), Carlson et al.
patent: 10034624 (2002-01-01), None
patent: 10034625 (2002-01-01), None
patent: 0 352 781 (1990-01-01), None
patent: 2003335762 (2003-11-01), None
patent: WO-93/23384 (1993-11-01), None
patent: WO-97/14690 (1997-04-01), None
patent: WO-97/27188 (1997-07-01), None
patent: WO-97/30995 (1997-08-01), None
patent: WO-97/31917 (1997-09-01), None
patent: WO-97/43280 (1997-11-01), None
patent: WO-98/01446 (1998-01-01), None
patent: WO-98/01447 (1998-01-01), None
patent: WO-99/10343 (1999-03-01), None
patent: WO-99/11642 (1999-03-01), None
patent: WO-99/10342 (1999-04-01), None
patent: WO-99/28317 (1999-06-01), None
patent: WO-99/33839 (1999-07-01), None
patent: WO-99/63937 (1999-12-01), None
patent: WO-99/64416 (1999-12-01), None
patent: WO-99/64417 (1999-12-01), None
patent: WO-00/21960 (2000-04-01), None
patent: WO-01/40222 (2001-06-01), None
patent: WO-01/40236 (2001-06-01), None
patent: WO-01/81350 (2001-11-01), None
patent: WO-01/94342 (2001-12-01), None
patent: WO-02/051819 (2002-07-01), None
patent: WO-02/080841 (2002-10-01), None
patent: WO-02/081468 (2002-10-01), None
patent: WO-02/081469 (2002-10-01), None
patent: WO-02/081470 (2002-10-01), None
patent: WO-02/096890 (2002-12-01), None
patent: WO-02/096916 (2002-12-01), None
patent: WO-02/096917 (2002-12-01), None
patent: WO-02/096918 (2002-12-01), None
patent: WO-03/006440 (2003-01-01), None
patent: WO-03/011859 (2003-02-01), None
patent: WO-03/031441 (2003-04-01), None
patent: WO-03/031443 (2003-04-01), None
patent: WO-03/035073 (2003-05-01), None
patent: WO-03/035648 (2003-05-01), None
patent: WO-03/072575 (2003-09-01), None
patent: WO-03/072576 (2003-09-01), None
patent: WO-2004/029066 (2004-04-01), None
U.S. Appl. No. 10/536,686.
Exp. Opin. Ther. Patents (1999) 9(5): 625-633.
Junior copending U.S. Appl. No. 10/536,686.
Gregory, W.A., et al., “Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 2. The ‘A’ Group,” J. Med. Chem., 33, 2569-2578 (1990).
Park, C.H., et al., “Antibacterials. Synthesis and Structure-Activity Studies of 3-Aryl-2-oxooxazolidines. 4. Multiply-Substituted Aryl Derivatives,” J. Med. Chem., 35, 1156-1165 (1992).
Pae, A.N., et al., “Synthesis and In Vitro Activity of New Oxazolidinone Antibacterial Agents Having Substituted Isoxazoles,” Bioorganic & Medicinal Chemistry Letters, 9, 2679-2684 (1999).

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