Oxazolidinedione derivatives and their use

Details Oxazolidinedione derivatives and their use Oxazolidinedione derivatives and their use

1995-11-06

1997-09-09

Fan, Jane

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

548203, 548226, 5462714, 514374, C07D27722, A61K 3142

Patent

active

056657480

ABSTRACT:
Novel 2,4-oxazolidinedione compounds of the formula: ##STR1## wherein R is a hydrocarbon residue or a heterocyclic group each of which may be substituted; Y is --CO--, --CH(OH)-- or --NR.sup.3 -- (wherein R.sup.3 is an alkyl group which may be substituted); m is 0 or 1; n is 0, 1 or 2; X is CH or N; A is bivalent straight or branched hydrocarbon chain residue having 1 to 7 carbon atoms; R.sup.1 and R.sup.2 each are hydrogen or an alkyl group, or R.sup.1 and R.sup.2 are combined with each other to form a 5- to 6-membered heterocyclic group optionally containing nitrogen; L and M each are hydrogen, or L and M are combined with each other to form a bond, or pharmaceutically acceptable salts thereof, having excellent hypoglycemic and hypolipidemic activities and are useful as anti-diabetics or hypolipidemic agents.

REFERENCES:
patent: 4430337 (1984-02-01), Holland
patent: 5037842 (1991-08-01), Goldstein
Sohda et al. Chem. Pharm. Bull 30(10) 3580-3600 1982.
Clark et al. CA 115:136086 1991.
Dow et al. CA 114:228799 1991.

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