Oxazole- and thiazole-alkanoic acid compounds

Details Oxazole- and thiazole-alkanoic acid compounds Oxazole- and thiazole-alkanoic acid compounds

1978-03-22

1979-11-20

Rizzo, Nicholas S.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

424272, 546275, 546280, 548187, 548228, C07D27720

Patent

active

041751302

ABSTRACT:
Oxazole- and thiazole-alkanoic acid compounds useful as drugs for the treatment of atherosclerosis with lipid metabolism disorder, and having the formula: ##STR1## wherein R is a hydrogen atom, an alkyl group having 1 to 4 carbon atoms, an aralkyl group, a pyridylmethyl group or a tocopheryl group; each of R.sup.1 and R.sup.2 is a hydrogen atom or a halogen atom; R.sup.3 is a hydrogen atom, a halogen atom or an alkyl group having 1 to 4 carbon atoms; R.sup.4 is a hydrogen atom, a halogen atom, a nitro group, an alkyl group having 1 to 4 carbon atoms, an alkoxy group having 1 to 4 carbon atoms or a trifuloromethyl group; each of X and Y is an oxygen atom or a sulfur atom; and A is a straight or branched alkylene group having 1 to 4 carbon atoms, and pharmaceutically acceptable salts thereof are disclosed.

REFERENCES:
patent: 2500142 (1950-03-01), Wiesehahn
patent: 4012412 (1977-03-01), Yamanaka et al.
patent: 4053478 (1977-10-01), Yamanaka et al.
JACS, vol. 72 (713138-3140 (1950).
CA, 44 7174-g (1950).
JCS, 4099-4106 (1952).

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