Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1986-10-10
1988-09-27
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514378, 546209, 548215, 548236, 548240, 548248, 548249, A61K 3142, C07D26106, C07D26330
Patent
active
047742534
ABSTRACT:
Oxazole and isoxazole derivatives of the formula ##STR1## wherein A is C.sub.1-6 -alkylene, Het is a 2-R-oxazol-5-yl, 5-R-oxazol-2-yl, 4-R-oxazol-2-yl, 2-R-oxazol-4-yl, 3-R-isoxazol-5-yl or 5-R-isoxazol-3-yl group which is optionally substituted on the heterocyclic ring by a C.sub.1-6 -alkyl group, R is phenyl or thienyl monosubstituted or disubstituted by halogen, trifluoromethyl or C.sub.1-6 -alkylthio, R.sup.1 and R.sup.2 each is a C.sub.1-6 -alkyl group and R.sup.3 is a hydroxy or C.sub.1-6 -alkoxy group or a group of the formula --NR.sup.4 R.sup.5 in which R.sup.4 and R.sup.5 each is a hydrogen atom or a C.sub.1-6 -alkyl group or R.sup.4 and R.sup.5 together with the nitrogen atom to which they are attached is a 5-membered or 6-membered saturated heteromonocyclic ring which may contain an oxygen or sulphur atom or an additional nitrogen atom, and pharmaceutically acceptable salts of the compounds of formula I in which R.sup.3 is a hydroxy group with bases, have anti-arthritic activity.
REFERENCES:
patent: 3470195 (1969-09-01), O'Mant
patent: 3642812 (1972-02-01), Southern
patent: 3652575 (1972-03-01), Hutton
patent: 4460596 (1984-07-01), Matsumoto
GCr 140838, D. P. Bloxham et al., Aug. 17, 1987.
GCr 140943, C. R. Self et al., Jan. 25, 1988.
Wyeth, Derwent No. 72056X, 7/9/76.
Hisamitsu, Derwent No. 85-300551, 21/10/85.
Ici, Derwent No. 30027F, 27/12/67.
S. J. Foster et al., Biochem. Pharmacol., 1983, 32(3), pp. 461-467.
Roche/Roche/Roche, Scrip No. 1145, Oct. 13, 1986, p. 27.
Machin Peter J.
Osbond John M.
Self Christopher R.
Smithen Carey E.
Tong Brian P.
Boxer Matthew
Daus Donald G.
Hoffmann-La Roche Inc.
Leon Bernard S.
Noel Mark W.
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