Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1974-05-28
1976-06-08
Drezin, Norman A.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
260243R, 260246, C07D26516, C07D27300, C07D29500
Patent
active
039622363
ABSTRACT:
Oxazinoindole derivatives characterized by having an amino(lower)alkyl radical attached to the 1 position of a 1H-1,4-oxazino[4,3-a]indole nucleus are disclosed. The amino portion of the amino(lower)alkyl radical may be further substituted with one or two lower alkyl groups or incorporated in a heterocyclic amine radical. The derivatives are substituted further at positions 1 and 10 and may be optionally substituted at positions 3, 4, 6, 7, 8 and 9. The oxazinoindole derivatives of this invention are useful antidepressant and antiulcer agents. Methods for the preparation and use of these derivatives are also disclosed.
REFERENCES:
patent: 3532719 (1970-10-01), Theimer
patent: 3676439 (1972-07-01), Hoffer
patent: 3833575 (1974-09-01), Demerson et al.
Rieche et al., "Synthetic Methods of Org. Chem." vol. 12, p. 361, S. Karger (pub.), New York (1958).
Warren et al., "Synthetic Methods of Org. Chem.", vol. 13, pp. 361-362, S. Karger (pub.), New York (1959).
Demerson Christopher A.
Dobson Thomas A.
Humber Leslie G.
Jirkovsky Ivo
Santroch George
Ayerst McKenna and Harrison Ltd.
Drezin Norman A.
Robinson Douglas W.
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