Oxazepam derivatives for immunoassay reagents

Details Oxazepam derivatives for immunoassay reagents Oxazepam derivatives for immunoassay reagents

1975-09-11

1977-08-23

Michl, Paul R.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2601125R, 260121, 2602393D, 424 85, 424 88, C07G 700

Patent

active

040439895

ABSTRACT:
Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine, which in turn are conjugated to antigenic polypeptides for formation of antibodies for use in immunoassays. The antibodies produced, when employed in immunoassays, are found to be able to detect the ingestion of a wide variety of benzdiazepine drugs as determined by positive results with the urine of the patient.

REFERENCES:
patent: 3520877 (1970-07-01), Fryer
patent: 3671518 (1972-06-01), Hellerbach
patent: 3799920 (1974-03-01), Ferrari
patent: 3801568 (1974-04-01), Nudelman
patent: 3825533 (1974-07-01), Nudelman

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