Oxazepam derivatives for immunoassay reagents

Drug – bio-affecting and body treating compositions – Identification or warning feature – Taste or smell or chemical irritation to the eye – nose – or...

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C07G 700, A61K 2900, G01N 3316

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active

042436540

ABSTRACT:
Compounds are provided for use in the preparation of reagents which can be used in immunoassays for benzdiazepines, particularly as their urinary metabolites. The compounds are non-oxo-carbonyl derivatives conjugated to the 3-position of the benzdiazepine, which in turn are conjugated to antigenic polypeptides for formation of antibodies for use in immunoassays. The antibodies produced, when employed in immunoassays, are found to be able to detect the ingestion of a wide variety of benzdiazepine drugs as determined by positive results with the urine of the patient.

REFERENCES:
patent: 3998943 (1976-12-01), Ullmann
patent: 4022878 (1977-05-01), Gross
patent: 4043989 (1977-08-01), Schneider et al.
patent: 4058511 (1977-11-01), Singh
patent: 4083948 (1978-04-01), Davis et al.
patent: 4104029 (1978-08-01), Maier

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