Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1990-08-24
1992-03-17
Berch, Mark L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
540347, 540360, 540361, A61K 3142, C07D498047, C07D20509, C07D20510
Patent
active
050968998
ABSTRACT:
Compounds of the structural formulae ##STR1## and their pharmaceutically acceptable salts, esters and amide derivatives, in which R.sup.1 and R.sup.2, independently of one another, denote hydrogen or pharmaceutically acceptable groups which have 1 to 10 carbon atoms and are bonded to the remaining part of the molecule via carbon-carbon single bonds, and in which R.sup.3, R.sup.4 and R.sup.5, independently of one another, denote pharmaceutically acceptable groups which have 1 to 10 carbon atoms and are bonded to the remaining part of the molecule via carbon-carbon single bonds, are useful antibiotics.
The trisubstitution by three groups R.sup.3, R.sup.4 and R.sup.5, which are bonded via carbon-carbon single bonds, results in a noticeable increase in the hydrolysis stability and thus also in the antibacterial action of axapenemcarboxylic acids.
REFERENCES:
Bentley JCS Chem. Comm.
Cherry, JCS Chem. Comm. 1978, 469-470.
Bentley J.C.S. Chem. Comm. 1977, 905.
Cherry, J.C.S. Chem. Comm. 1978, 469-470.
Current Antibicrobial Patents 1989, pp. 1067-1068.
Hendel Wolfram
Pfaendler Hans R.
Bayer Aktiengesellschaft
Berch Mark L.
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