Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – N-c doai
Patent
1987-01-14
1989-04-11
Springer, David B.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
N-c doai
562433, 548252, 548253, C07C10314, A61K 31165
Patent
active
048207268
ABSTRACT:
4-Acylresorcinol esthers of the formula ##STR1## in which R.sub.1 is lower alkyl, R.sub.2 is fluorinated lower alkyl, R.sub.3 is hydrogen, lower alkoxy, trifluoromethyl or halogen, alk is an alkylene or hydroxyalkylene radical which is uninterrupted or interrupted by oxygen, one of the radicals R.sub.4, R.sub.5 and R.sub.7 is a group of the formula --NH--C(.dbd.O)--R.sub.8, a radical R.sub.4 or R.sub.5 which differs from this is a radical R.sub.9 and a radical R.sub.7 which differs from this is a radical R.sub.10, R.sub.6 is hydrogen, lower alkyl, trifluoromethyl, halogen, carboxyl which is free, esterified or amidated, cyano or lower alkanoyl, R.sub.8 is carboxyl which is free, esterified or amidated or 5-tetrazolyl, R.sub.9 is hydrogen, lower alkyl, lower alkoxy, halogen or trifluoromethyl and R.sub.10 is hydrogen, lower alkyl, lower alkoxy, halogen, trifluoromethyl, cyano or carboxyl which is free, esterified or amidated, and their salts have antiallergic and antiinflammatory properties. They are prepared, for example, by reacting compounds of the formulae ##STR2## in which one of the radicals X.sub.5 and X.sub.6 is hydroxyl which is free or in salt form and the other is an alkoxy radical substituted by reactive esterified hydroxy or epoxy. The invention also relates to intermediates of the formula ##STR3## in which R.sub.2 is fluorinated lower alkyl, R.sub.3 is hydrogen, lower alkoxy, trifluoromethyl or halogen and R.sub.11 is hydrogen or a group of the formula R.sub.1 --C(--O)--, in which R.sub.1 is lower alkyl, and their salts.
REFERENCES:
patent: 4119783 (1978-10-01), Hall et al.
patent: 4159278 (1979-07-01), Hall et al.
patent: 4442115 (1984-04-01), Ramsden et al.
patent: 4507498 (1985-03-01), Carson et al.
Beck Andreas
Lang Robert W.
Sallmann Alfred
Wenk Paul
Ciba-Geigy Corporation
Fishman Irving M.
Springer David B.
Villamizar JoAnn
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