Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using a micro-organism to make a protein or polypeptide
Reexamination Certificate
2011-04-05
2011-04-05
Swope, Sheridan (Department: 1652)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using a micro-organism to make a protein or polypeptide
C435S254100
Reexamination Certificate
active
07919275
ABSTRACT:
An isolated mutant host cell produced by disrupting or deleting, in a parent cell, a nucleic acid sequence encoding an oxaloacetate hydrolase, or a promoter thereof, which results in the mutant cell producing less of the oxaloacetate hydrolase than the parent cell is disclosed. The disclosure also relates to recombinant methods for producing the products such as polypeptides.
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Kasatkina et al., Mikrobiologiya, 34:511-518 (1965) translated to Kasatkina et al., On Methods of Selecting Aspergillus Niger Mutants with Altered Capacity to Synthesize Organic Acids, Mikrobiologiya, vol. 94, No. 3, pp. 438-444 (1965).
Kasatkina et al., Mikrobiologiya, 34:511-518 (1965).
Sambrook et al., Molecular Cloning, a laboratory manual, 2ndedition (1989).
Gayle et al. “Identification of regions in interleukin-1 alpha important for activity”, J. Biol Chem., vol. 268, No. 29, pp. 22105-22111 (1993).
Whisstock et al., “Prediction of protein function from protein sequence and structure”, Q Rev Biophys, vol. 36, No. 3, pp. 307-340 (2003).
William B. A. et al, EMBL, Database Genbank, Acc. No. T82752 2000 (Sep. 18, 2000).
Hjort Carsten Mailand
Nielsen Jens
Pedersen Henrik
Krenicky Michael W.
Novozymes A/S
Swope Sheridan
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