Oxaloacetate hydrolase deficient fungal host cells

Details Oxaloacetate hydrolase deficient fungal host cells Oxaloacetate hydrolase deficient fungal host cells

2011-04-05

2011-04-05

Swope, Sheridan (Department: 1652)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using a micro-organism to make a protein or polypeptide

C435S254100

Reexamination Certificate

active

07919275

ABSTRACT:
An isolated mutant host cell produced by disrupting or deleting, in a parent cell, a nucleic acid sequence encoding an oxaloacetate hydrolase, or a promoter thereof, which results in the mutant cell producing less of the oxaloacetate hydrolase than the parent cell is disclosed. The disclosure also relates to recombinant methods for producing the products such as polypeptides.

REFERENCES:
patent: 1999 00231 (1991-02-01), None
patent: 2089615 (1997-09-01), None
patent: WO 94/23022 (1994-10-01), None
patent: WO 00/50576 (2000-08-01), None
Pedersen et al, Construction and characterization of an oxalic acid nonproducing strain of Aspergillus niger. Metab Eng. Jan. 2000;2(1):34-41.
William B. A. et al, EMBL, Database Genbank, Acc. No. T82752 2000 (Sep. 18, 2000).
Ruijter et al., Oxalic acid production by Apergillus Niger, Microbiology, vol. 145, pp. 2569-2576 (1999).
Lenz et al., Partial Purification and Some Properties of Oxalacetase from Aspergillus niger, Eur. J. Biochem, vol. 65, pp. 225-236 (1976).
Balmforth et al., Isolation and characterization of glyoxylate dehydrogenase from the fungus Sclerotium rolfsii, Biochem. J., vol. 218, pp. 113-118 (1984).
William B. A. et al, EMBL, Database Genbank, Acc. No. T82752 (Mar. 15, 1995).
Shcherbakova et al., The Variability of Aspergillus niger, pp. 432-436, translated from Microbiology, vol. 43, pp. 508-513 (1974).
Kasatkina et al., On Methods of Selecting Aspergillus Niger Mutants with Altered Capacity to Synthesize Organic Acids, Mikrobiologiya, vol. 94, No. 3, pp. 438-444 (1965).
Kubicek et al., Evidence for a Cytoplasmic Pathway of Oxalate Biosynthesis in Aspergillus Niger, Applied and Environmental Microbiology, vol. 54, pp. 633-637 (1988).
Van Den Hombergh, J. et al., Aspergillus As a Host for Heterologous Protein, Trends in Biotechnology, vol. 15, No. 7, pp. 256-263 (1997).
Schrickx et al., Organic Acid Production by Aspergillus Niger, Analytical Biochemistry, vol. 231, pp. 175-181 (1995).
Brown et al., Exploring the New World of the Genome with DNA, vol. 21, pp. 33-37 (1999).
SIGMA Inc., Diagnostic Kit for Oxalate, p. 2455 (1997).
Hossain et al., The Effect of the Sugar Source on Citric Acid, vol. 19, No. 6, pp. 393-397 (1984).
Sambrook et al., Molecular Cloning, a laboratory manual, 2ndedition (1989).
Van Den Hombergh et al., Curr Genet, 28:299-308 (1995).
Gayle et al. “Identification of regions in interleukin-1 alpha important for activity”, J. Biol Chem., vol. 268, No. 29, pp. 22105-22111 (1993).
Whisstock et al., “Prediction of protein function from protein sequence and structure”, Q Rev Biophys, vol. 36, No. 3, pp. 307-340 (2003).
Golubtsova et al., Changes in the Ratio between Citric and Oxalic Acids in Aspergillus Niger under the Action of Mutagenic Factors, Mikrobiologiya, vol. XLVIII, Issue 6 (1979) (and a translation thereof) USSR.
Kasatkina et al., Mikrobiologiya, 34:511-518 (1965) translated to Kasatkina et al., On Methods of Selecting Aspergillus Niger Mutants with Altered Capacity to Synthesize Organic Acids, Mikrobiologiya, vol. 94, No. 3, pp. 438-444 (1965).
Kasatkina et al., Mikrobiologiya, 34:511-518 (1965).
Sambrook et al., Molecular Cloning, a laboratory manual, 2ndedition (1989).
Gayle et al. “Identification of regions in interleukin-1 alpha important for activity”, J. Biol Chem., vol. 268, No. 29, pp. 22105-22111 (1993).
Whisstock et al., “Prediction of protein function from protein sequence and structure”, Q Rev Biophys, vol. 36, No. 3, pp. 307-340 (2003).
William B. A. et al, EMBL, Database Genbank, Acc. No. T82752 2000 (Sep. 18, 2000).

Affiliated with

Also associated with

Rating

Oxaloacetate hydrolase deficient fungal host cells does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Oxaloacetate hydrolase deficient fungal host cells, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Oxaloacetate hydrolase deficient fungal host cells will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2690035