Oxadiazolotriazine derivatives

Details Oxadiazolotriazine derivatives Oxadiazolotriazine derivatives

1981-02-17

1982-06-22

Ford, John M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

544196, 544197, C07D25166

Patent

active

043363806

ABSTRACT:
Oxadiazolotriazine derivatives of the formula ##STR1## wherein R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, are described.
A process for preparing compounds of formula I wherein R.sup.1 is hydrogen, R.sup.2 is a group of the formula --COOR.sup.5, wherein R.sup.5 is as hereinafter set forth, and R.sup.3 is as hereinafter set forth, by cyclizing an intermediate of the formula ##STR2## wherein R.sup.3 and R.sup.5 are as hereinafter set forth, is also described. The compounds of formula I are useful in the treatment of vascular-condition hypertension or also as vasodilators in the case of peripheral blood supply disorders.

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Abstract of British Patent Specification 1,025,902, pub. 1-1963.
Zins, J. Pharmacol. Expt. Therap., vol. 150, No. 1, pp. 109-117 (1965).
Schroder et al., Arzneimittelchemise I, Thieme-Verlag Stutgart, p. 33 (1976).

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