Oxadiazolopyrimidine derivatives

Details Oxadiazolopyrimidine derivatives Oxadiazolopyrimidine derivatives

1982-08-13

1983-10-18

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Four or more ring nitrogens in the bicyclo ring system

C07D49822, A61K 31505

Patent

active

044106980

ABSTRACT:
Oxadiazolo[2,3-c]pyrimidine derivatives of the formula ##STR1## wherein R is alkyl, alkenyl, alkynyl or alkoxyalkyl, as well as their salts, are described. The compounds of formula I have valuable, long-lasting vasodilating and/or blood pressure-lowering properties and are useful for the treatment of vascular-conditioned hypertensions or as vasodilators in peripheral blood supply disorders. The compounds are prepared, inter alia, by carbamoylating the corresponding derivative containing a free amino group and optional salt formation.

REFERENCES:
patent: 4150131 (1979-04-01), Muller et al.
patent: 4150132 (1979-04-01), Muller et al.
patent: 4360521 (1982-11-01), Hengartner et al.

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