Oxacephalosporins

Details Oxacephalosporins Oxacephalosporins

1981-11-19

1983-01-18

Raymond, Richard

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

542420, 542443, 544 3, 544 54, 544 586, 544 69, C07D49804

Patent

active

043693148

ABSTRACT:
New oxacephalosporin derivative of the general formula: ##STR1## in which R.sub.1 is a protective radical, R.sub.2 is either a radical of the general formula: ##STR2## [in which R.sub.5 is hydrogen, alkyl, vinyl, protected carboxyalkyl or a protective radical and R.sub.6 is a protective radical] or an .alpha.-carboxyarylacetyl radical and R" is hydrogen or methoxy in the 7.alpha.-position, or alternatively R.sub.2 is a protective radical and R" is either hydrogen or methoxy in the 7.alpha.-position or hydrogen in the 7.beta.-position, and R.sub.3 and R.sub.4 are optionally substituted alkyl, or phenyl, or form a heterocyclic ring with the nitrogen atom, their E and Z forms and mixtures thereof and also their preparation.
These new products are useful as intermediates for the preparation of biologically active oxacephalosporins.

REFERENCES:
patent: 4143038 (1979-03-01), Narisada et al.
patent: 4201782 (1980-05-01), Narisada et al.
patent: 4304774 (1981-12-01), Katner

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