Oxabispidine compounds useful in the treatment of cardiac...

Details Oxabispidine compounds useful in the treatment of cardiac... Oxabispidine compounds useful in the treatment of cardiac...

2007-01-16

2007-01-16

Kifle, Bruck (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

Reexamination Certificate

active

10317195

ABSTRACT:
There is provided compounds of formula I,wherein R1, R2, R3, R4, R41to R46, A, B and G have meanings given in the description, which are useful in the prophylaxis and in the treatment of arrhythmias, in particular atrial and ventricular arrhythmias.

REFERENCES:
patent: 3196154 (1965-07-01), Steck
patent: 3503939 (1970-03-01), Williams
patent: 4459301 (1984-07-01), Binnig et al.
patent: 4556662 (1985-12-01), Binnig et al.
patent: 5140033 (1992-08-01), Schriewer et al.
patent: 5468858 (1995-11-01), Berlin et al.
patent: 5831099 (1998-11-01), Dave et al.
patent: 6291475 (2001-09-01), Alstermark et al.
patent: 6492382 (2002-12-01), Bjore et al.
patent: 6559162 (2003-05-01), Bjorsne et al.
patent: 6887881 (2005-05-01), Bjor et al.
patent: 0 125 826 (1984-11-01), None
patent: 0 308 843 (1989-09-01), None
patent: 1 256 850 (1971-12-01), None
patent: 62-84070 (1987-04-01), None
patent: WO 91/07405 (1991-05-01), None
patent: 99/31100 (1999-06-01), None
patent: WO 00/61569 (2000-04-01), None
patent: WO 01/28992 (2001-04-01), None
patent: WO 01/28992 (2001-04-01), None
Paudler, W.W. et al., “3,7-Disubstituted Octahydro-1,5-diazocines . . . ” J. Org. Chem., Aug. 1967, vol. 32, pp. 2425-2430.
Mueller, Claus D., et al; “Eljárás biszpidin-származékok elöállítására”;Hungarian Patent Office; Application No. P8200945 (Mar. 26, 1982), Publication No. 29934 (Feb. 28, 1984) (abstract).
Nemec et al.; “Pharmacotherapy of atrial fibrillation”; Expert Opinion on Pharmacotherapy; Ashley Publications Ltd., ISSN 1465-6566; 1999.
“Special Report; Preliminary Report: Effect of encainide and flecainide . . . ,” New England Journal of Medicine, vol. 321, No. 6, pp. 406-412 (1989).
Zh. Obshch. Khim., vol. 33, No. 9, pp. 3110-3112 (1963).
J. Med. Chem., vol. 39, p. 2559 (1996).
Pharmacol. Res., vol. 24, p. 149 (1991).
Circulation 90, p. 2032 (1994).
Anal. Sci., vol. 9, p. 429 (1993).
Stetter et al, “Synthese des 1,3-Diaza-6-oxa-adamantans,” Chem. Ber. vol. 96, No. 11, pp. 2827-2830 (1963).
Villa et al, “3,8-Diazabicyclo . . . ,” Eur. J. Med. Chem., vol. 36, pp. 495-506 (2001).
Stetter et al, “Syntheses des 1,3-Diaza-6-oxa-adamantans,” Chem. Ber. vol. 96, No. 11, pp. 2829-2830 (1963).
Sorokin et al, “Reaction ob Bis(2,3-epoxypropyl)butylamine . . . ,” J. Org. Chem.USSR(Eng. transl.) 2150-2153 (1971).
Chapman, et al, Difluoramination of Heterocyclic Ketones: Control . . . , J. Org. Chem. vol. 63, pp. 1566-1570 (1998).
Chapman et al, “Nitrolysis of a Highly Deactivated Amide . . . ,” J. Org. Chem., vol. 64, pp. 960-965 (1999).
Dave et al, “Facile Preparation of 3,7-Diazabicyclo[3.3.0]octane . . . , ” J. Org. Chem., vol. 61, pp. 8897-8903 (1996).
Nelson et al, “The Synthesis of 2,5- and 2,6- . . . ” J. Org. Chem. vol. 36, No. 22, pp. 3361-3365 (1971).
Paulder et al, “3,7-Disubstituted Octahydro . . . ,” pp. 2425-2431 (1967).
Paulder et al, “1,5-Bis-p-toluenesfonyl) . . . , ” pp. 277-281 (1966).
Abstract No. 1987:637909.
Abstract No. 1987-146842.
Lange et al, “Facile Conversion of Primary . . . , ” Synthetic Communications, vol. 20, No. 10, pp. 1473-1479 (1990).
Steck, et al;J. Org. Chem.; 28(9)2233-8 (1963).
Chem. Abs. vol. 56, 1962, No. 154911, Nikitskya et al,Zh. Obshich, 31, 3202-5 (1961).
Chem. Abs. vol. 59, 1963, No. 7474h, Cignarelli et al; Gazz. Chim. Ital, 93(4), 320-8 (1963).
Chem. Abs. vol. 59, 1963, No. 2822c, Cignarelli et al, Chim. Ital, 93, 226-37 (1963).
Chem. Abs. vol. 46, 1952, No. 992f, Zu-Yoong Kyi et al, J. Chem. Soc. (1963) 1706-8.
Chem. Abs. vol. 48, 1954, No. 2068d, Roderick A. Barnes et al, J.Am. Chem. Soc. 75, 975-7 (1953).
Chem. Abs. vol. 55, 1961, No. 19010d, M.V. Rubtsov et al, J. Med. Pharm. Chem. 3, 441-60 (1961).
Paritosh, R. Dave et al; J. Org. Chem. 1996, 61, 8897-8903.

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