Ovulation kit comprising FSH isoforms with varying half-lives

Details Ovulation kit comprising FSH isoforms with varying half-lives Ovulation kit comprising FSH isoforms with varying half-lives

1991-08-28

1993-11-16

Hill, Jr., Robert J.

Chemistry: natural resins or derivatives; peptides or proteins;

Peptides of 3 to 100 amino acid residues

Lutenizing hormone releasing factor ; related peptides

435975, C07K 1300, A61K 3738, A61K 3700

Patent

active

052625184

ABSTRACT:
A therapy kit for inducing human ovulation is disclosed. The kit comprises, in separate containers, at least two recombinant FSH isoforms having significantly different plasma half-lives. The FSH isoforms are administered sequentially, beginning with the isoform having the longer plasma half-life.

REFERENCES:
Chappel et al. 1986 Acta Endocrinology 113: 311-316.
Chappel et al. 1983. Biosyn. & Secretion of FSH. Endocrine Reviews 4(2): 179.
Harlin et al. 1986. Mole. Comp. of FH and FSH in Commercial Gonadotropia Preps. Fertility & Sterility 46(6): 1055.
Chappel et al., Endocrinology 115:452, 1984.
Dahl et al., Science 239:72, 1988.
Blum et al., J. Endocr. 105:29, 1985.
Vaitukaitis et al., Chem. Abstracts 75:126325b.
Grodecka et al., Chem. Abstracts 94:11840r.
Morell et al., Chem. Abstracts 74:96321g.

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